Bridging integrator 2 (BIN2)

About Bridging integrator 2

Bridging integrator 2 (BIN2) is a protein from Homo sapiens identified by UniProt accession Q9UBW5, 565 residues long. MolForge cross-references it against 0 known binders and 116 disease associations.

Target properties

Protein name	Bridging integrator 2
UniProt accession	Q9UBW5
Gene	BIN2
Organism	Homo sapiens
Length	565 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (116)

Diseases linked to this target (Open Targets).

mean platelet volume · score 0.52
cancer · score 0.46
basophil count · score 0.40
platelet count · score 0.40
basophil percentage of leukocytes · score 0.30
neutrophil count · score 0.24
lymphocyte count · score 0.18
inflammatory bowel disease · score 0.16
platelet component distribution width · score 0.15
myeloid white cell count · score 0.14

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBW5-F1	alphafold	PREDICTED	64.56	—

Amino-acid sequence (565 residues)

MAEGKAGGAA GLFAKQVQKK FSRAQEKVLQ KLGKAVETKD ERFEQSASNF YQQQAEGHKL YKDLKNFLSA VKVMHESSKR VSETLQEIYS SEWDGHEELK AIVWNNDLLW EDYEEKLADQ AVRTMEIYVA QFSEIKERIA KRGRKLVDYD SARHHLEAVQ NAKKKDEAKT AKAEEEFNKA QTVFEDLNQE LLEELPILYN SRIGCYVTIF QNISNLRDVF YREMSKLNHN LYEVMSKLEK QHSNKVFVVK GLSSSSRRSL VISPPVRTAT VSSPLTSPTS PSTLSLKSES ESVSATEDLA PDAAQGEDNS EIKELLEEEE IEKEGSEASS SEEDEPLPAC NGPAQAQPSP TTERAKSQEE VLPSSTTPSP GGALSPSGQP SSSATEVVLR TRTASEGSEQ PKKRASIQRT SAPPSRPPPP RATASPRPSS GNIPSSPTAS GGGSPTSPRA SLGTGTASPR TSLEVSPNPE PPEKPVRTPE AKENENIHNQ NPEELCTSPT LMTSQVASEP GEAKKMEDKE KDNKLISANS SEGQDQLQVS MVPENNNLTA PEPQEEVSTS ENPQL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards