COP9 signalosome complex subunit 7a (COPS7A)

About COP9 signalosome complex subunit 7a

COP9 signalosome complex subunit 7a (COPS7A) is a protein from Homo sapiens identified by UniProt accession Q9UBW8, 275 residues long. MolForge cross-references it against 0 known binders and 34 disease associations.

Target properties

Protein name	COP9 signalosome complex subunit 7a
UniProt accession	Q9UBW8
Gene	COPS7A
Organism	Homo sapiens
Length	275 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (34)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.38
lung adenocarcinoma · score 0.18
red blood cell density measurement · score 0.16
BMI-adjusted hip circumference · score 0.14
erythrocyte count · score 0.12
arterial stiffness measurement · score 0.11
smoking status measurement · score 0.08
sex hormone-binding globulin measurement · score 0.07
insomnia measurement · score 0.03
Hearing abnormality · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBW8-F1	alphafold	PREDICTED	84.63	—

Amino-acid sequence (275 residues)

MSAEVKVTGQ NQEQFLLLAK SAKGAALATL IHQVLEAPGV YVFGELLDMP NVRELAESDF ASTFRLLTVF AYGTYADYLA EARNLPPLTE AQKNKLRHLS VVTLAAKVKC IPYAVLLEAL ALRNVRQLED LVIEAVYADV LRGSLDQRNQ RLEVDYSIGR DIQRQDLSAI ARTLQEWCVG CEVVLSGIEE QVSRANQHKE QQLGLKQQIE SEVANLKKTI KVTTAAAAAA TSQDPEQHLT ELREPAPGTN QRQPSKKASK GKGLRGSAKI WSKSN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards