Homeobox expressed in ES cells 1 (HESX1)

About Homeobox expressed in ES cells 1

Homeobox expressed in ES cells 1 (HESX1) is a protein from Homo sapiens identified by UniProt accession Q9UBX0, 185 residues long. MolForge cross-references it against 0 known binders and 121 disease associations.

Target properties

Protein name	Homeobox expressed in ES cells 1
UniProt accession	Q9UBX0
Gene	HESX1
Organism	Homo sapiens
Length	185 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (121)

Diseases linked to this target (Open Targets).

septooptic dysplasia · score 0.83
Combined pituitary hormone deficiencies, genetic forms · score 0.81
Septo-optic dysplasia · score 0.80
pituitary hormone deficiency, combined, 1 · score 0.47
genetic disorder · score 0.46
pituitary stalk interruption syndrome · score 0.37
Kallmann syndrome · score 0.37
hypothyroidism due to deficient transcription factors involved in pituitary development or function · score 0.37
Male infertility with spermatogenesis disorder · score 0.27
amenorrhea · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBX0-F1	alphafold	PREDICTED	71.83	—

Amino-acid sequence (185 residues)

MSPSLQEGAQ LGENKPSTCS FSIERILGLD QKKDCVPLMK PHRPWADTCS SSGKDGNLCL HVPNPPSGIS FPSVVDHPMP EERASKYENY FSASERLSLK RELSWYRGRR PRTAFTQNQI EVLENVFRVN CYPGIDIRED LAQKLNLEED RIQIWFQNRR AKLKRSHRES QFLMAKKNFN TNLLE

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards