Double homeobox protein 4 (DUX4)

About Double homeobox protein 4

Double homeobox protein 4 (DUX4) is a protein from Homo sapiens identified by UniProt accession Q9UBX2, 424 residues long. MolForge cross-references it against 0 known binders and 13 disease associations.

Target properties

Protein name	Double homeobox protein 4
UniProt accession	Q9UBX2
Gene	DUX4
Organism	Homo sapiens
Length	424 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (13)

Diseases linked to this target (Open Targets).

Facioscapulohumeral dystrophy · score 0.39
facioscapulohumeral muscular dystrophy · score 0.08
urinary albumin to creatinine ratio · score 0.04
albuminuria · score 0.04
cancer · score 0.02
neoplasm · score 0.01
myopathy · score 0.01
sarcoma · score 0.01
hemophilia A · score 0.00
Ewing sarcoma · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBX2-F1	alphafold	PREDICTED	61.44	—

Amino-acid sequence (424 residues)

MALPTPSDST LPAEARGRGR RRRLVWTPSQ SEALRACFER NPYPGIATRE RLAQAIGIPE PRVQIWFQNE RSRQLRQHRR ESRPWPGRRG PPEGRRKRTA VTGSQTALLL RAFEKDRFPG IAAREELARE TGLPESRIQI WFQNRRARHP GQGGRAPAQA GGLCSAAPGG GHPAPSWVAF AHTGAWGTGL PAPHVPCAPG ALPQGAFVSQ AARAAPALQP SQAAPAEGIS QPAPARGDFA YAAPAPPDGA LSHPQAPRWP PHPGKSREDR DPQRDGLPGP CAVAQPGPAQ AGPQGQGVLA PPTSQGSPWW GWGRGPQVAG AAWEPQAGAA PPPQPAPPDA SASARQGQMQ GIPAPSQALQ EPAPWSALPC GLLLDELLAS PEFLQQAQPL LETEAPGELE ASEEAASLEA PLSEEEYRAL LEEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards