About Kallikrein-11
Kallikrein-11 (KLK11) is a protein
from Homo sapiens identified by UniProt accession
Q9UBX7, 282 residues long.
MolForge cross-references it against 0 known binders and
189 disease associations.
Target properties
| Protein name | Kallikrein-11 |
|---|
| UniProt accession | Q9UBX7 |
|---|
| Gene | KLK11 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 282 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (189)
Diseases linked to this target (Open Targets).
- ichthyosis with erythrokeratoderma · score 0.51
- kallikrein-11 measurement · score 0.38
- blood protein measurement · score 0.36
- vitamin D measurement · score 0.21
- genetic disorder · score 0.19
- neurodegenerative disease · score 0.15
- Ichthyosis-hypotrichosis syndrome · score 0.08
- kallikrein-12 measurement · score 0.08
- erythrokeratodermia variabilis · score 0.08
- cholangiocarcinoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBX7-F1 | alphafold | PREDICTED | 82.75 | — |
Amino-acid sequence (282 residues)
MQRLRWLRDW KSSGRGLTAA KEPGARSSPL QAMRILQLIL LALATGLVGG ETRIIKGFEC KPHSQPWQAA LFEKTRLLCG ATLIAPRWLL TAAHCLKPRY IVHLGQHNLQ KEEGCEQTRT ATESFPHPGF NNSLPNKDHR NDIMLVKMAS PVSITWAVRP LTLSSRCVTA GTSCLISGWG STSSPQLRLP HTLRCANITI IEHQKCENAY PGNITDTMVC ASVQEGGKDS CQGDSGGPLV CNQSLQGIIS WGQDPCAITR KPGVYTKVCK YVDWIQETMK NN
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