Lysophosphatidic acid receptor 3 (LPAR3)

About Lysophosphatidic acid receptor 3

Lysophosphatidic acid receptor 3 (LPAR3) is a protein from Homo sapiens identified by UniProt accession Q9UBY5, 353 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.

Target properties

Protein name	Lysophosphatidic acid receptor 3
UniProt accession	Q9UBY5
Gene	LPAR3
Organism	Homo sapiens
Length	353 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (130)

Diseases linked to this target (Open Targets).

heel bone mineral density · score 0.47
bone quantitative ultrasound measurement · score 0.38
PHF-tau measurement · score 0.31
urate measurement · score 0.30
bone density · score 0.30
t-tau:beta-amyloid 1-42 ratio measurement · score 0.30
glioblastoma multiforme · score 0.26
ovarian cancer · score 0.24
metabolite measurement · score 0.12
lung adenocarcinoma · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBY5-F1	alphafold	PREDICTED	81.43	—

Amino-acid sequence (353 residues)

MNECHYDKHM DFFYNRSNTD TVDDWTGTKL VIVLCVGTFF CLFIFFSNSL VIAAVIKNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN RWFLRQGLLD SSLTASLTNL LVIAVERHMS IMRMRVHSNL TKKRVTLLIL LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLVF WTVSNLMAFL IMVVVYLRIY VYVKRKTNVL SPHTSGSISR RRTPMKLMKT VMTVLGAFVV CWTPGLVVLL LDGLNCRQCG VQHVKRWFLL LALLNSVVNP IIYSYKDEDM YGTMKKMICC FSQENPERRP SRIPSTVLSR SDTGSQYIED SISQGAVCNK STS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards