Protein CLN8 (CLN8)

About Protein CLN8

Protein CLN8 (CLN8) is a protein from Homo sapiens identified by UniProt accession Q9UBY8, 286 residues long. MolForge cross-references it against 0 known binders and 194 disease associations.

Target properties

Protein name	Protein CLN8
UniProt accession	Q9UBY8
Gene	CLN8
Organism	Homo sapiens
Length	286 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (194)

Diseases linked to this target (Open Targets).

neuronal ceroid lipofuscinosis 8 · score 0.83
CLN8 disease · score 0.81
neuronal ceroid lipofuscinosis 8 northern epilepsy variant · score 0.69
Progressive epilepsy - intellectual disability, Finnish type · score 0.67
neuronal ceroid lipofuscinosis · score 0.66
genetic disorder · score 0.50
systolic blood pressure · score 0.35
glycine encephalopathy · score 0.34
basal cell carcinoma · score 0.34
total cholesterol change measurement · score 0.32

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UBY8-F1	alphafold	PREDICTED	90.09	—

Amino-acid sequence (286 residues)

MNPASDGGTS ESIFDLDYAS WGIRSTLMVA GFVFYLGVFV VCHQLSSSLN ATYRSLVARE KVFWDLAATR AVFGVQSTAA GLWALLGDPV LHADKARGQQ NWCWFHITTA TGFFCFENVA VHLSNLIFRT FDLFLVIHHL FAFLGFLGCL VNLQAGHYLA MTTLLLEMST PFTCVSWMLL KAGWSESLFW KLNQWLMIHM FHCRMVLTYH MWWVCFWHWD GLVSSLYLPH LTLFLVGLAL LTLIINPYWT HKKTQQLLNP VDWNFAQPEA KSRPEGNGQL LRKKRP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards