About DNA-(apurinic or apyrimidinic site) endonuclease 2
DNA-(apurinic or apyrimidinic site) endonuclease 2 (APEX2) is a protein
from Homo sapiens identified by UniProt accession
Q9UBZ4, 518 residues long.
MolForge cross-references it against 0 known binders and
146 disease associations.
Target properties
| Protein name | DNA-(apurinic or apyrimidinic site) endonuclease 2 |
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| UniProt accession | Q9UBZ4 |
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| Gene | APEX2 |
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| Organism | Homo sapiens |
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| Length | 518 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (146)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.22
- cancer · score 0.09
- ringed hair disease · score 0.08
- Griscelli syndrome type 3 · score 0.08
- uncombable hair syndrome · score 0.08
- Blackfan-Diamond anemia · score 0.07
- Griscelli disease type 3 · score 0.07
- Griscelli disease · score 0.07
- Microcephaly - albinism - digital anomalies · score 0.06
- microcephaly-albinism-digital anomalies syndrome · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UBZ4-F1 | alphafold | PREDICTED | 78.35 | — |
Amino-acid sequence (518 residues)
MLRVVSWNIN GIRRPLQGVA NQEPSNCAAV AVGRILDELD ADIVCLQETK VTRDALTEPL AIVEGYNSYF SFSRNRSGYS GVATFCKDNA TPVAAEEGLS GLFATQNGDV GCYGNMDEFT QEELRALDSE GRALLTQHKI RTWEGKEKTL TLINVYCPHA DPGRPERLVF KMRFYRLLQI RAEALLAAGS HVIILGDLNT AHRPIDHWDA VNLECFEEDP GRKWMDSLLS NLGCQSASHV GPFIDSYRCF QPKQEGAFTC WSAVTGARHL NYGSRLDYVL GDRTLVIDTF QASFLLPEVM GSDHCPVGAV LSVSSVPAKQ CPPLCTRFLP EFAGTQLKIL RFLVPLEQSP VLEQSTLQHN NQTRVQTCQN KAQVRSTRPQ PSQVGSSRGQ KNLKSYFQPS PSCPQASPDI ELPSLPLMSA LMTPKTPEEK AVAKVVKGQA KTSEAKDEKE LRTSFWKSVL AGPLRTPLCG GHREPCVMRT VKKPGPNLGR RFYMCARPRG PPTDPSSRCN FFLWSRPS
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