CAP-Gly domain-containing linker protein 2 (CLIP2)

About CAP-Gly domain-containing linker protein 2

CAP-Gly domain-containing linker protein 2 (CLIP2) is a protein from Homo sapiens identified by UniProt accession Q9UDT6, 1046 residues long. MolForge cross-references it against 0 known binders and 18 disease associations.

Target properties

Protein name	CAP-Gly domain-containing linker protein 2
UniProt accession	Q9UDT6
Gene	CLIP2
Organism	Homo sapiens
Length	1046 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (18)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.41
blood protein measurement · score 0.28
autism spectrum disorder symptom · score 0.24
total blood protein measurement · score 0.03
Familial isolated hypoparathyroidism · score 0.03
sex hormone-binding globulin measurement · score 0.03
systemic lupus erythematosus · score 0.02
Williams syndrome · score 0.02
Werner syndrome · score 0.01
Cognitive impairment · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UDT6-F1	alphafold	PREDICTED	73.79	—

Amino-acid sequence (1046 residues)

MQKPSGLKPP GRGGKHSSPM GRTSTGSASS SAAVAASSKE GSPLHKQSSG PSSSPAAAAA PEKPGPKAAE VGDDFLGDFV VGERVWVNGV KPGVVQYLGE TQFAPGQWAG VVLDDPVGKN DGAVGGVRYF ECPALQGIFT RPSKLTRQPT AEGSGSDAHS VESLTAQNLS LHSGTATPPL TSRVIPLRES VLNSSVKTGN ESGSNLSDSG SVKRGEKDLR LGDRVLVGGT KTGVVRYVGE TDFAKGEWCG VELDEPLGKN DGAVAGTRYF QCPPKFGLFA PIHKVIRIGF PSTSPAKAKK TKRMAMGVSA LTHSPSSSSI SSVSSVASSV GGRPSRSGLL TETSSRYARK ISGTTALQEA LKEKQQHIEQ LLAERDLERA EVAKATSHIC EVEKEIALLK AQHEQYVAEA EEKLQRARLL VESVRKEKVD LSNQLEEERR KVEDLQFRVE EESITKGDLE TQTQLEHARI GELEQSLLLE KAQAERLLRE LADNRLTTVA EKSRVLQLEE ELTLRRGEIE ELQQCLLHSG PPPPDHPDAA EILRLRERLL SASKEHQRES GVLRDKYEKA LKAYQAEVDK LRAANEKYAQ EVAGLKDKVQ QATSENMGLM DNWKSKLDSL ASDHQKSLED LKATLNSGPG AQQKEIGELK AVMEGIKMEH QLELGNLQAK HDLETAMHVK EKEALREKLQ EAQEELAGLQ RHWRAQLEVQ ASQHRLELQE AQDQRRDAEL RVHELEKLDV EYRGQAQAIE FLKEQISLAE KKMLDYERLQ RAEAQGKQEV ESLREKLLVA ENRLQAVEAL CSSQHTHMIE SNDISEETIR TKETVEGLQD KLNKRDKEVT ALTSQTEMLR AQVSALESKC KSGEKKVDAL LKEKRRLEAE LETVSRKTHD ASGQLVLISQ ELLRKERSLN ELRVLLLEAN RHSPGPERDL SREVHKAEWR IKEQKLKDDI RGLREKLTGL DKEKSLSDQR RYSLIDRSSA PELLRLQHQL MSTEDALRDA LDQAQQVEKL MEAMRSCPDK AQTIGNSGSA NGIHQQDKAQ KQEDKH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards