Tripartite motif-containing protein 10 (TRIM10)

About Tripartite motif-containing protein 10

Tripartite motif-containing protein 10 (TRIM10) is a protein from Homo sapiens identified by UniProt accession Q9UDY6, 481 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Tripartite motif-containing protein 10
UniProt accession	Q9UDY6
Gene	TRIM10
Organism	Homo sapiens
Length	481 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

reticulocyte count · score 0.57
reticulocyte measurement · score 0.56
mean reticulocyte volume · score 0.52
Red cell distribution width · score 0.46
Immature Reticulocyte Fraction Measurement · score 0.42
schizophrenia · score 0.09
autism spectrum disorder · score 0.09
acute myeloid leukemia · score 0.07
unipolar depression · score 0.07
upper aerodigestive tract neoplasm · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UDY6-F1	alphafold	PREDICTED	89.87	—

Amino-acid sequence (481 residues)

MASAASVTSL ADEVNCPICQ GTLREPVTID CGHNFCRACL TRYCEIPGPD LEESPTCPLC KEPFRPGSFR PNWQLANVVE NIERLQLVST LGLGEEDVCQ EHGEKIYFFC EDDEMQLCVV CREAGEHATH TMRFLEDAAA PYREQIHKCL KCLRKEREEI QEIQSRENKR MQVLLTQVST KRQQVISEFA HLRKFLEEQQ SILLAQLESQ DGDILRQRDE FDLLVAGEIC RFSALIEELE EKNERPAREL LTDIRSTLIR CETRKCRKPV AVSPELGQRI RDFPQQALPL QREMKMFLEK LCFELDYEPA HISLDPQTSH PKLLLSEDHQ RAQFSYKWQN SPDNPQRFDR ATCVLAHTGI TGGRHTWVVS IDLAHGGSCT VGVVSEDVQR KGELRLRPEE GVWAVRLAWG FVSALGSFPT RLTLKEQPRQ VRVSLDYEVG WVTFTNAVTR EPIYTFTASF TRKVIPFFGL WGRGSSFSLS S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards