Macrophage receptor MARCO (MARCO)

About Macrophage receptor MARCO

Macrophage receptor MARCO (MARCO) is a protein from Homo sapiens identified by UniProt accession Q9UEW3, 520 residues long. MolForge cross-references it against 0 known binders and 247 disease associations.

Target properties

Protein name	Macrophage receptor MARCO
UniProt accession	Q9UEW3
Gene	MARCO
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (247)

Diseases linked to this target (Open Targets).

triglyceride measurement · score 0.38
serum albumin measurement · score 0.31
total blood protein measurement · score 0.31
blood protein measurement · score 0.28
Inhalant adrenergic use measurement · score 0.28
neurodegenerative disease · score 0.26
squamous cell lung carcinoma · score 0.23
lung adenocarcinoma · score 0.19
head and neck squamous cell carcinoma · score 0.19
glioblastoma multiforme · score 0.19

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UEW3-F1	alphafold	PREDICTED	58.35	—

Amino-acid sequence (520 residues)

MRNKKILKED ELLSETQQAA FHQIAMEPFE INVPKPKRRN GVNFSLAVVV IYLILLTAGA GLLVVQVLNL QARLRVLEMY FLNDTLAAED SPSFSLLQSA HPGEHLAQGA SRLQVLQAQL TWVRVSHEHL LQRVDNFTQN PGMFRIKGEQ GAPGLQGHKG AMGMPGAPGP PGPPAEKGAK GAMGRDGATG PSGPQGPPGV KGEAGLQGPQ GAPGKQGATG TPGPQGEKGS KGDGGLIGPK GETGTKGEKG DLGLPGSKGD RGMKGDAGVM GPPGAQGSKG DFGRPGPPGL AGFPGAKGDQ GQPGLQGVPG PPGAVGHPGA KGEPGSAGSP GRAGLPGSPG SPGATGLKGS KGDTGLQGQQ GRKGESGVPG PAGVKGEQGS PGLAGPKGAP GQAGQKGDQG VKGSSGEQGV KGEKGERGEN SVSVRIVGSS NRGRAEVYYS GTWGTICDDE WQNSDAIVFC RMLGYSKGRA LYKVGAGTGQ IWLDNVQCRG TESTLWSCTK NSWGHHDCSH EEDAGVECSV

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards