About Leucine-rich repeat and WD repeat-containing protein 1
Leucine-rich repeat and WD repeat-containing protein 1 (LRWD1) is a protein
from Homo sapiens identified by UniProt accession
Q9UFC0, 647 residues long.
MolForge cross-references it against 0 known binders and
19 disease associations.
Target properties
| Protein name | Leucine-rich repeat and WD repeat-containing protein 1 |
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| UniProt accession | Q9UFC0 |
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| Gene | LRWD1 |
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| Organism | Homo sapiens |
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| Length | 647 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (19)
Diseases linked to this target (Open Targets).
- mean platelet volume · score 0.17
- appendicular lean mass · score 0.07
- chronotype measurement · score 0.07
- insomnia measurement · score 0.07
- diabetes mellitus · score 0.03
- type 2 diabetes mellitus · score 0.03
- Ewing sarcoma · score 0.03
- embryonal carcinoma · score 0.01
- Testicular Embryonal Carcinoma · score 0.01
- Sertoli Cell-Only Syndrome · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UFC0-F1 | alphafold | PREDICTED | 83.46 | — |
Amino-acid sequence (647 residues)
MGPLSARLLM QRGRPKSDRL GKIRSLDLSG LELLSEHLDP KLLCRLTQLQ ELDLSNNHLE TLPDNLGLSH LRVLRCANNQ LGDVTALCQF PKLEELSLEG NPFLTVNDNL KVSFLLPTLR KVNGKDASST YSQVENLNRE LTSRVTAHWE KFMATLGPEE EAEKAQADFV KSAVRDVRYG PESLSEFTQW RVRMISEELV AASRTQVQKA NSPEKPPEAG AAHKPRARLA ALKRPDDVPL SLSPSKRACA SPSAQVEGSP VAGSDGSQPA VKLEPLHFLQ CHSKNNSPQD LETQLWACAF EPAWEEGATS QTVATCGGEA VCVIDCQTGI VLHKYKAPGE EFFSVAWTAL MVVTQAGHKK RWSVLAAAGL RGLVRLLHVR AGFCCGVIRA HKKAIATLCF SPAHETHLFT ASYDKRIILW DIGVPNQDYE FQASQLLTLD TTSIPLRLCP VASCPDARLL AGCEGGCCCW DVRLDQPQKR RVCEVEFVFS EGSEASGRRV DGLAFVNEDI VASKGSGLGT ICLWSWRQTW GGRGSQSTVA VVVLARLQWS STELAYFSLS ACPDKGIVLC GDEEGNVWLY DVSNILKQPP LLPAALQAPT QILKWPQPWA LGQVVTKTMV NTVVANASFT YLTALTDSNI VAIWGRM
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