Golgi-associated kinase 1A (GASK1A)

About Golgi-associated kinase 1A

Golgi-associated kinase 1A (GASK1A) is a protein from Homo sapiens identified by UniProt accession Q9UFP1, 575 residues long. MolForge cross-references it against 0 known binders and 11 disease associations.

Target properties

Protein name	Golgi-associated kinase 1A
UniProt accession	Q9UFP1
Gene	GASK1A
Organism	Homo sapiens
Length	575 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (11)

Diseases linked to this target (Open Targets).

body height · score 0.39
insomnia measurement · score 0.29
BMI-adjusted waist circumference · score 0.28
sitting height measurement · score 0.28
Knee pain · score 0.26
neurofibrillary tangles measurement · score 0.04
monocyte count · score 0.04
CCL11 measurement · score 0.02
Acute hepatic failure · score 0.02
colorectal cancer · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UFP1-F1	alphafold	PREDICTED	68.43	—

Amino-acid sequence (575 residues)

MASWLRRKLR GKRRPVIAFC LLMILSAMAV TRFPPQRPSA GPDPGPMEPQ GVTGAPATHI RQALSSSRRQ RARNMGFWRS RALPRNSILV CAEEQGHRAR VDRSRESPGG DLRHPGRVRR DITLSGHPRL STQHVVLLRE DEVGDPGTKD LGHPQHGSPI QETQSEVVTL VSPLPGSDMA ALPAWRATSG LTLWPHTAEG RDLLGAENRA LTGGQQAEDP TLASGAHQWP GSVEKLQGSV WCDAETLLSS SRTGGQAPPW LTDHDVQMLR LLAQGEVVDK ARVPAHGQVL QVGFSTEAAL QDLSSPRLSQ LCSQGLCGLI KRPGDLPEVL SFHVDRVLGL RRSLPAVARR FHSPLLPYRY TDGGARPVIW WAPDVQHLSD PDEDQNSLAL GWLQYQALLA HSCNWPGQAP CPGIHHTEWA RLALFDFLLQ VHDRLDRYCC GFEPEPSDPC VEERLREKCQ NPAELRLVHI LVRSSDPSHL VYIDNAGNLQ HPEDKLNFRL LEGIDGFPES AVKVLASGCL QNMLLKSLQM DPVFWESQGG AQGLKQVLQT LEQRGQVLLG HIQKHNLTLF RDEDP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards