GTPase IMAP family member 2 (GIMAP2)

About GTPase IMAP family member 2

GTPase IMAP family member 2 (GIMAP2) is a protein from Homo sapiens identified by UniProt accession Q9UG22, 337 residues long. MolForge cross-references it against 0 known binders and 39 disease associations.

Target properties

Protein name	GTPase IMAP family member 2
UniProt accession	Q9UG22
Gene	GIMAP2
Organism	Homo sapiens
Length	337 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (39)

Diseases linked to this target (Open Targets).

oral squamous cell carcinoma · score 0.07
eosinophil count · score 0.05
hematocrit · score 0.04
eosinophil percentage of leukocytes · score 0.03
high density lipoprotein cholesterol measurement · score 0.02
clear cell renal carcinoma · score 0.02
diastolic blood pressure · score 0.02
lung carcinoma · score 0.02
ovarian carcinoma · score 0.02
astrocytoma · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UG22-F1	alphafold	PREDICTED	88.94	—

Amino-acid sequence (337 residues)

MDQNEHSHWG PHAKGQCASR SELRIILVGK TGTGKSAAGN SILRKQAFES KLGSQTLTKT CSKSQGSWGN REIVIIDTPD MFSWKDHCEA LYKEVQRCYL LSAPGPHVLL LVTQLGRYTS QDQQAAQRVK EIFGEDAMGH TIVLFTHKED LNGGSLMDYM HDSDNKALSK LVAACGGRIC AFNNRAEGSN QDDQVKELMD CIEDLLMEKN GDHYTNGLYS LIQRSKCGPV GSDERVKEFK QSLIKYMETQ RSYTALAEAN CLKGALIKTQ LCVLFCIQLF LRLIILWLCI LHSMCNLFCC LLFSMCNLFC SLLFIIPKKL MIFLRTVIRL ERKTPRL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards