About Phosphatidylserine decarboxylase proenzyme, mitochondrial
Phosphatidylserine decarboxylase proenzyme, mitochondrial (PISD) is a protein
from Homo sapiens identified by UniProt accession
Q9UG56, 409 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Phosphatidylserine decarboxylase proenzyme, mitochondrial |
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| UniProt accession | Q9UG56 |
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| Gene | PISD |
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| Organism | Homo sapiens |
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| Length | 409 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (46)
Diseases linked to this target (Open Targets).
- Liberfarb syndrome · score 0.69
- genetic disorder · score 0.19
- skeletal dysplasia · score 0.19
- Skeletal dysplasia · score 0.19
- deafness · score 0.18
- glioblastoma multiforme · score 0.18
- microcephaly · score 0.18
- Microcephaly · score 0.18
- Cataract · score 0.18
- Intellectual disability · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UG56-F1 | alphafold | PREDICTED | 77.60 | — |
Amino-acid sequence (409 residues)
MATSVGHRCL GLLHGVAPWR SSLHPCEITA LSQSLQPLRK LPFRAFRTDA RKIHTAPART MFLLRPLPIL LVTGGGYAGY RQYEKYRERE LEKLGLEIPP KLAGHWEVAL YKSVPTRLLS RAWGRLNQVE LPHWLRRPVY SLYIWTFGVN MKEAAVEDLH HYRNLSEFFR RKLKPQARPV CGLHSVISPS DGRILNFGQV KNCEVEQVKG VTYSLESFLG PRMCTEDLPF PPAASCDSFK NQLVTREGNE LYHCVIYLAP GDYHCFHSPT DWTVSHRRHF PGSLMSVNPG MARWIKELFC HNERVVLTGD WKHGFFSLTA VGATNVGSIR IYFDRDLHTN SPRHSKGSYN DFSFVTHTNR EGVPMRKGEH LGEFNLGSTI VLIFEAPKDF NFQLKTGQKI RFGEALGSL
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