About ATP-binding cassette sub-family F member 2
ATP-binding cassette sub-family F member 2 (ABCF2) is a protein
from Homo sapiens identified by UniProt accession
Q9UG63, 623 residues long.
MolForge cross-references it against 0 known binders and
42 disease associations.
Target properties
| Protein name | ATP-binding cassette sub-family F member 2 |
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| UniProt accession | Q9UG63 |
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| Gene | ABCF2 |
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| Organism | Homo sapiens |
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| Length | 623 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (42)
Diseases linked to this target (Open Targets).
- serum IgG glycosylation measurement · score 0.19
- body height · score 0.17
- alkaline phosphatase measurement · score 0.16
- heel bone mineral density · score 0.16
- neurodegenerative disease · score 0.16
- total blood protein measurement · score 0.15
- hemoglobin measurement · score 0.14
- interleukin 5 receptor subunit alpha measurement · score 0.13
- femoral neck bone mineral density · score 0.13
- red blood cell density measurement · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UG63-F1 | alphafold | PREDICTED | 83.32 | — |
Amino-acid sequence (623 residues)
MPSDLAKKKA AKKKEAAKAR QRPRKGHEEN GDVVTEPQVA EKNEANGRET TEVDLLTKEL EDFEMKKAAA RAVTGVLASH PNSTDVHIIN LSLTFHGQEL LSDTKLELNS GRRYGLIGLN GIGKSMLLSA IGKREVPIPE HIDIYHLTRE MPPSDKTPLH CVMEVDTERA MLEKEAERLA HEDAECEKLM ELYERLEELD ADKAEMRASR ILHGLGFTPA MQRKKLKDFS GGWRMRVALA RALFIRPFML LLDEPTNHLD LDACVWLEEE LKTFKRILVL VSHSQDFLNG VCTNIIHMHN KKLKYYTGNY DQYVKTRLEL EENQMKRFHW EQDQIAHMKN YIARFGHGSA KLARQAQSKE KTLQKMMASG LTERVVSDKT LSFYFPPCGK IPPPVIMVQN VSFKYTKDGP CIYNNLEFGI DLDTRVALVG PNGAGKSTLL KLLTGELLPT DGMIRKHSHV KIGRYHQHLQ EQLDLDLSPL EYMMKCYPEI KEKEEMRKII GRYGLTGKQQ VSPIRNLSDG QKCRVCLAWL AWQNPHMLFL DEPTNHLDIE TIDALADAIN EFEGGMMLVS HDFRLIQQVA QEIWVCEKQT ITKWPGDILA YKEHLKSKLV DEEPQLTKRT HNV
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