About Ubiquitin thioesterase ZRANB1
Ubiquitin thioesterase ZRANB1 (ZRANB1) is a protein
from Homo sapiens identified by UniProt accession
Q9UGI0, 708 residues long.
MolForge cross-references it against 0 known binders and
117 disease associations.
Target properties
| Protein name | Ubiquitin thioesterase ZRANB1 |
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| UniProt accession | Q9UGI0 |
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| Gene | ZRANB1 |
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| Organism | Homo sapiens |
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| Length | 708 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (117)
Diseases linked to this target (Open Targets).
- body mass index · score 0.48
- body height · score 0.46
- erythrocyte count · score 0.43
- age at menopause · score 0.40
- lean body mass · score 0.40
- red blood cell density measurement · score 0.39
- eosinophil count · score 0.37
- appendicular lean mass · score 0.37
- prostate carcinoma · score 0.36
- fat body mass · score 0.34
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGI0-F1 | alphafold | PREDICTED | 76.89 | — |
Amino-acid sequence (708 residues)
MSERGIKWAC EYCTYENWPS AIKCTMCRAQ RPSGTIITED PFKSGSSDVG RDWDPSSTEG GSSPLICPDS SARPRVKSSY SMENANKWSC HMCTYLNWPR AIRCTQCLSQ RRTRSPTESP QSSGSGSRPV AFSVDPCEEY NDRNKLNTRT QHWTCSVCTY ENWAKAKRCV VCDHPRPNNI EAIELAETEE ASSIINEQDR ARWRGSCSSG NSQRRSPPAT KRDSEVKMDF QRIELAGAVG SKEELEVDFK KLKQIKNRMK KTDWLFLNAC VGVVEGDLAA IEAYKSSGGD IARQLTADEV RLLNRPSAFD VGYTLVHLAI RFQRQDMLAI LLTEVSQQAA KCIPAMVCPE LTEQIRREIA ASLHQRKGDF ACYFLTDLVT FTLPADIEDL PPTVQEKLFD EVLDRDVQKE LEEESPIINW SLELATRLDS RLYALWNRTA GDCLLDSVLQ ATWGIYDKDS VLRKALHDSL HDCSHWFYTR WKDWESWYSQ SFGLHFSLRE EQWQEDWAFI LSLASQPGAS LEQTHIFVLA HILRRPIIVY GVKYYKSFRG ETLGYTRFQG VYLPLLWEQS FCWKSPIALG YTRGHFSALV AMENDGYGNR GAGANLNTDD DVTITFLPLV DSERKLLHVH FLSAQELGNE EQQEKLLREW LDCCVTEGGV LVAMQKSSRR RNHPLVTQMV EKWLDRYRQI RPCTSLSDGE EDEDDEDE
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