About 5'-AMP-activated protein kinase subunit gamma-3
5'-AMP-activated protein kinase subunit gamma-3 (PRKAG3) is a protein
from Homo sapiens identified by UniProt accession
Q9UGI9, 489 residues long.
MolForge cross-references it against 0 known binders and
71 disease associations.
Target properties
| Protein name | 5'-AMP-activated protein kinase subunit gamma-3 |
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| UniProt accession | Q9UGI9 |
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| Gene | PRKAG3 |
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| Organism | Homo sapiens |
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| Length | 489 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (71)
Diseases linked to this target (Open Targets).
- cardiovascular disease · score 0.30
- breast adenocarcinoma · score 0.29
- lung adenocarcinoma · score 0.28
- glioblastoma multiforme · score 0.27
- ovarian cancer · score 0.25
- head and neck squamous cell carcinoma · score 0.24
- squamous cell lung carcinoma · score 0.22
- triglyceride measurement · score 0.20
- sex hormone-binding globulin measurement · score 0.19
- esophageal cancer · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGI9-F1 | alphafold | PREDICTED | 68.95 | — |
Amino-acid sequence (489 residues)
MEPGLEHALR RTPSWSSLGG SEHQEMSFLE QENSSSWPSP AVTSSSERIR GKRRAKALRW TRQKSVEEGE PPGQGEGPRS RPAAESTGLE ATFPKTTPLA QADPAGVGTP PTGWDCLPSD CTASAAGSST DDVELATEFP ATEAWECELE GLLEERPALC LSPQAPFPKL GWDDELRKPG AQIYMRFMQE HTCYDAMATS SKLVIFDTML EIKKAFFALV ANGVRAAPLW DSKKQSFVGM LTITDFILVL HRYYRSPLVQ IYEIEQHKIE TWREIYLQGC FKPLVSISPN DSLFEAVYTL IKNRIHRLPV LDPVSGNVLH ILTHKRLLKF LHIFGSLLPR PSFLYRTIQD LGIGTFRDLA VVLETAPILT ALDIFVDRRV SALPVVNECG QVVGLYSRFD VIHLAAQQTY NHLDMSVGEA LRQRTLCLEG VLSCQPHESL GEVIDRIARE QVHRLVLVDE TQHLLGVVSL SDILQALVLS PAGIDALGA
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