About 5'-AMP-activated protein kinase subunit gamma-2
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2) is a protein
from Homo sapiens identified by UniProt accession
Q9UGJ0, 569 residues long.
MolForge cross-references it against 0 known binders and
249 disease associations.
Target properties
| Protein name | 5'-AMP-activated protein kinase subunit gamma-2 |
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| UniProt accession | Q9UGJ0 |
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| Gene | PRKAG2 |
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| Organism | Homo sapiens |
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| Length | 569 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (249)
Diseases linked to this target (Open Targets).
- hypertrophic cardiomyopathy 6 · score 0.79
- lethal congenital glycogen storage disease of heart · score 0.78
- Wolff-Parkinson-White Syndrome · score 0.76
- hypertrophic cardiomyopathy · score 0.76
- cardiomyopathy · score 0.58
- Rare familial disorder with hypertrophic cardiomyopathy · score 0.54
- Abnormality of the cardiovascular system · score 0.50
- Glycogen storage disease due to phosphorylase kinase deficiency · score 0.46
- familial hypertrophic cardiomyopathy · score 0.41
- glomerular filtration rate · score 0.38
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGJ0-F1 | alphafold | PREDICTED | 66.43 | — |
Amino-acid sequence (569 residues)
MGSAVMDTKK KKDVSSPGGS GGKKNASQKR RSLRVHIPDL SSFAMPLLDG DLEGSGKHSS RKVDSPFGPG SPSKGFFSRG PQPRPSSPMS APVRPKTSPG SPKTVFPFSY QESPPRSPRR MSFSGIFRSS SKESSPNSNP ATSPGGIRFF SRSRKTSGLS SSPSTPTQVT KQHTFPLESY KHEPERLENR IYASSSPPDT GQRFCPSSFQ SPTRPPLASP THYAPSKAAA LAAALGPAEA GMLEKLEFED EAVEDSESGV YMRFMRSHKC YDIVPTSSKL VVFDTTLQVK KAFFALVANG VRAAPLWESK KQSFVGMLTI TDFINILHRY YKSPMVQIYE LEEHKIETWR ELYLQETFKP LVNISPDASL FDAVYSLIKN KIHRLPVIDP ISGNALYILT HKRILKFLQL FMSDMPKPAF MKQNLDELGI GTYHNIAFIH PDTPIIKALN IFVERRISAL PVVDESGKVV DIYSKFDVIN LAAEKTYNNL DITVTQALQH RSQYFEGVVK CNKLEILETI VDRIVRAEVH RLVVVNEADS IVGIISLSDI LQALILTPAG AKQKETETE
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