About Gamma-tubulin complex component 4
Gamma-tubulin complex component 4 (TUBGCP4) is a protein
from Homo sapiens identified by UniProt accession
Q9UGJ1, 667 residues long.
MolForge cross-references it against 0 known binders and
57 disease associations.
Target properties
| Protein name | Gamma-tubulin complex component 4 |
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| UniProt accession | Q9UGJ1 |
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| Gene | TUBGCP4 |
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| Organism | Homo sapiens |
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| Length | 667 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (57)
Diseases linked to this target (Open Targets).
- microcephaly and chorioretinopathy 3 · score 0.75
- microcephaly and chorioretinopathy 1 · score 0.63
- ovarian cancer · score 0.23
- breast adenocarcinoma · score 0.23
- genetic disorder · score 0.19
- glycine measurement · score 0.14
- bilirubin measurement · score 0.14
- eosinophil count · score 0.13
- age at menopause · score 0.11
- neurodegenerative disease · score 0.10
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGJ1-F1 | alphafold | PREDICTED | 81.98 | — |
Amino-acid sequence (667 residues)
MIHELLLALS GYPGSIFTWN KRSGLQVSQD FPFLHPSETS VLNRLCRLGT DYIRFTEFIE QYTGHVQQQD HHPSQQGQGG LHGIYLRAFC TGLDSVLQPY RQALLDLEQE FLGDPHLSIS HVNYFLDQFQ LLFPSVMVVV EQIKSQKIHG CQILETVYKH SCGGLPPVRS ALEKILAVCH GVMYKQLSAW MLHGLLLDQH EEFFIKQGPS SGNVSAQPEE DEEDLGIGGL TGKQLRELQD LRLIEEENML APSLKQFSLR VEILPSYIPV RVAEKILFVG ESVQMFENQN VNLTRKGSIL KNQEDTFAAE LHRLKQQPLF SLVDFEQVVD RIRSTVAEHL WKLMVEESDL LGQLKIIKDF YLLGRGELFQ AFIDTAQHML KTPPTAVTEH DVNVAFQQSA HKVLLDDDNL LPLLHLTIEY HGKEHKADAT QAREGPSRET SPREAPASGW AALGLSYKVQ WPLHILFTPA VLEKYNVVFK YLLSVRRVQA ELQHCWALQM QRKHLKSNQT DAIKWRLRNH MAFLVDNLQY YLQVDVLESQ FSQLLHQINS TRDFESIRLA HDHFLSNLLA QSFILLKPVF HCLNEILDLC HSFCSLVSQN LGPLDERGAA QLSILVKGFS RQSSLLFKIL SSVRNHQINS DLAQLLLRLD YNKYYTQAGG TLGSFGM
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