About Signal-transducing adaptor protein 2
Signal-transducing adaptor protein 2 (STAP2) is a protein
from Homo sapiens identified by UniProt accession
Q9UGK3, 403 residues long.
MolForge cross-references it against 0 known binders and
46 disease associations.
Target properties
| Protein name | Signal-transducing adaptor protein 2 |
|---|
| UniProt accession | Q9UGK3 |
|---|
| Gene | STAP2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 403 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (46)
Diseases linked to this target (Open Targets).
- vitamin D measurement · score 0.27
- protein measurement · score 0.20
- endometrial cancer · score 0.18
- lung adenocarcinoma · score 0.18
- gastric adenocarcinoma · score 0.12
- mean corpuscular hemoglobin · score 0.05
- hematocrit · score 0.04
- mean corpuscular volume · score 0.04
- cancer · score 0.03
- chronic myelogenous leukemia · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGK3-F1 | alphafold | PREDICTED | 71.01 | — |
Amino-acid sequence (403 residues)
MASALRPPRV PKPKGVLPSH YYESFLEKKG PCDRDYKKFW AGLQGLTIYF YNSNRDFQHV EKLNLGAFEK LTDEIPWGSS RDPGTHFSLI LRDQEIKFKV ETLECREMWK GFILTVVELR VPTDLTLLPG HLYMMSEVLA KEEARRALET PSCFLKVSRL EAQLLLERYP ECGNLLLRPS GDGADGVSVT TRQMHNGTHV VRHYKVKREG PKYVIDVEQP FSCTSLDAVV NYFVSHTKKA LVPFLLDEDY EKVLGYVEAD KENGENVWVA PSAPGPGPAP CTGGPKPLSP ASSQDKLPPL PPLPNQEENY VTPIGDGPAV DYENQDVASS SWPVILKPKK LPKPPAKLPK PPVGPKPEPK VFNGGLGRKL PVSSAQPLFP TAGLADMTAE LQKKLEKRRA LEH
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