About Secretion-regulating guanine nucleotide exchange factor
Secretion-regulating guanine nucleotide exchange factor (SERGEF) is a protein
from Homo sapiens identified by UniProt accession
Q9UGK8, 458 residues long.
MolForge cross-references it against 0 known binders and
21 disease associations.
Target properties
| Protein name | Secretion-regulating guanine nucleotide exchange factor |
|---|
| UniProt accession | Q9UGK8 |
|---|
| Gene | SERGEF |
|---|
| Organism | Homo sapiens |
|---|
| Length | 458 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (21)
Diseases linked to this target (Open Targets).
- body height · score 0.30
- mean corpuscular volume · score 0.29
- sitting height measurement · score 0.18
- platelet count · score 0.18
- leukocyte count · score 0.15
- self reported educational attainment · score 0.15
- alcohol consumption measurement · score 0.12
- neutrophil count · score 0.11
- lymphocyte count · score 0.04
- type 2 diabetes mellitus · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGK8-F1 | alphafold | PREDICTED | 85.24 | — |
Amino-acid sequence (458 residues)
MEREPSASEA APAAAALFAW GANSYGQLGL GHKEDVLLPQ QLNDFCKPRS VRRITGGGGH SAVVTDGGDL FVCGLNKDGQ LGLGHTEDIP YFTPCKSLFG CPIQQVACGW DFTIMLTENG QVLSCGSNSF GQLGVPHGPR RCVVPQAIEL HKEKVVCIAA GLRHAVAATA SGIVFQWGTG LASCGRRLCP GQTLPLFFTA KEPSRVTGLE NSKAMCVLAG SDHSASLTDA GEVYVWGSNK HGQLANEAAF LPVPQKIEAH CFQNEKVTAI WSGWTHLVAQ TETGKMFTWG RADYGQLGRK LETYEGWKLE KQDSFLPCSR PPNSMPSSPH CLTGATEVSC GSEHNLAIIG GVCYSWGWNE HGMCGDGTEA NVWAPKPVQA LLSSSGLLVG CGAGHSLALC QLPAHPALVQ DPKVTYLSPD AIEDTESQKA MDKERNWKER QSETSTQSQS DWSRNGGL
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