Tryptophan--tRNA ligase, mitochondrial (WARS2)

About Tryptophan--tRNA ligase, mitochondrial

Tryptophan--tRNA ligase, mitochondrial (WARS2) is a protein from Homo sapiens identified by UniProt accession Q9UGM6, 360 residues long. MolForge cross-references it against 0 known binders and 142 disease associations.

Target properties

Protein name	Tryptophan--tRNA ligase, mitochondrial
UniProt accession	Q9UGM6
Gene	WARS2
Organism	Homo sapiens
Length	360 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (142)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder, mitochondrial, with abnormal movements and lactic acidosis, with or without seizures · score 0.82
parkinsonism-dystonia 3, childhood-onset · score 0.71
neurodegenerative disease · score 0.56
genetic disorder · score 0.41
cortical surface area measurement · score 0.40
balding measurement · score 0.37
neuroimaging measurement · score 0.37
mitochondrial disease · score 0.37
brain measurement · score 0.37
hair shape measurement · score 0.36

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UGM6-F1	alphafold	PREDICTED	89.75	—

Amino-acid sequence (360 residues)

MALHSMRKAR ERWSFIRALH KGSAAAPALQ KDSKKRVFSG IQPTGILHLG NYLGAIESWV RLQDEYDSVL YSIVDLHSIT VPQDPAVLRQ SILDMTAVLL ACGINPEKSI LFQQSQVSEH TQLSWILSCM VRLPRLQHLH QWKAKTTKQK HDGTVGLLTY PVLQAADILL YKSTHVPVGE DQVQHMELVQ DLAQGFNKKY GEFFPVPESI LTSMKKVKSL RDPSAKMSKS DPDKLATVRI TDSPEEIVQK FRKAVTDFTS EVTYDPAGRA GVSNIVAVHA AVTGLSVEEV VRRSAGMNTA RYKLAVADAV IEKFAPIKRE IEKLKLDKDH LEKVLQIGSA KAKELAYTVC QEVKKLVGFL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards