About Translocation protein SEC63 homolog
Translocation protein SEC63 homolog (SEC63) is a protein
from Homo sapiens identified by UniProt accession
Q9UGP8, 760 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Translocation protein SEC63 homolog |
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| UniProt accession | Q9UGP8 |
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| Gene | SEC63 |
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| Organism | Homo sapiens |
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| Length | 760 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- Isolated polycystic liver disease · score 0.77
- autosomal dominant polycystic liver disease · score 0.53
- neurodegenerative disease · score 0.53
- polycystic liver disease 1 · score 0.46
- APOL1 risk genotype carrier status · score 0.36
- donor genotype effect measurement · score 0.36
- renal transplant outcome measurement · score 0.36
- genetic disorder · score 0.19
- autosomal dominant medullary cystic kidney disease with or without hyperuricemia · score 0.11
- Abnormality of the liver · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGP8-F1 | alphafold | PREDICTED | 77.36 | — |
Amino-acid sequence (760 residues)
MAGQQFQYDD SGNTFFYFLT SFVGLIVIPA TYYLWPRDQN AEQIRLKNIR KVYGRCMWYR LRLLKPQPNI IPTVKKIVLL AGWALFLFLA YKVSKTDREY QEYNPYEVLN LDPGATVAEI KKQYRLLSLK YHPDKGGDEV MFMRIAKAYA ALTDEESRKN WEEFGNPDGP QATSFGIALP AWIVDQKNSI LVLLVYGLAF MVILPVVVGS WWYRSIRYSG DQILIRTTQI YTYFVYKTRN MDMKRLIMVL AGASEFDPQY NKDATSRPTD NILIPQLIRE IGSINLKKNE PPLTCPYSLK ARVLLLSHLA RMKIPETLEE DQQFMLKKCP ALLQEMVNVI CQLIVMARNR EEREFRAPTL ASLENCMKLS QMAVQGLQQF KSPLLQLPHI EEDNLRRVSN HKKYKIKTIQ DLVSLKESDR HTLLHFLEDE KYEEVMAVLG SFPYVTMDIK SQVLDDEDSN NITVGSLVTV LVKLTRQTMA EVFEKEQSIC AAEEQPAEDG QGETNKNRTK GGWQQKSKGP KKTAKSKKKK PLKKKPTPVL LPQSKQQKQK QANGVVGNEA AVKEDEEEVS DKGSDSEEEE TNRDSQSEKD DGSDRDSDRE QDEKQNKDDE AEWQELQQSI QRKERALLET KSKITHPVYS LYFPEEKQEW WWLYIADRKE QTLISMPYHV CTLKDTEEVE LKFPAPGKPG NYQYTVFLRS DSYMGLDQIK PLKLEVHEAK PVPENHPQWD TAIEGDEDQE DSEGFEDSFE EEEEEEEDDD
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