About Transcription factor 20
Transcription factor 20 (TCF20) is a protein
from Homo sapiens identified by UniProt accession
Q9UGU0, 1960 residues long.
MolForge cross-references it against 0 known binders and
128 disease associations.
Target properties
| Protein name | Transcription factor 20 |
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| UniProt accession | Q9UGU0 |
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| Gene | TCF20 |
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| Organism | Homo sapiens |
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| Length | 1960 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (128)
Diseases linked to this target (Open Targets).
- developmental delay with variable intellectual impairment and behavioral abnormalities · score 0.75
- Intellectual disability · score 0.56
- Neurodevelopmental abnormality · score 0.53
- genetic disorder · score 0.52
- Neurodevelopmental delay · score 0.46
- Global developmental delay · score 0.46
- autism · score 0.44
- Intellectual disability, mild · score 0.43
- Generalized hypotonia · score 0.42
- chronotype measurement · score 0.41
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGU0-F1 | alphafold | PREDICTED | 38.91 | — |
Amino-acid sequence (1960 residues)
MQSFREQSSY HGNQQSYPQE VHGSSRLEEF SPRQAQMFQN FGGTGGSSGS SGSGSGGGRR GAAAAAAAMA SETSGHQGYQ GFRKEAGDFY YMAGNKDPVT TGTPQPPQRR PSGPVQSYGP PQGSSFGNQY GSEGHVGQFQ AQHSGLGGVS HYQQDYTGPF SPGSAQYQQQ ASSQQQQQQV QQLRQQLYQS HQPLPQATGQ PASSSSHLQP MQRPSTLPSS AAGYQLRVGQ FGQHYQSSAS SSSSSSFPSP QRFSQSGQSY DGSYNVNAGS QYEGHNVGSN AQAYGTQSNY SYQPQSMKNF EQAKIPQGTQ QGQQQQQPQQ QQHPSQHVMQ YTNAATKLPL QSQVGQYNQP EVPVRSPMQF HQNFSPISNP SPAASVVQSP SCSSTPSPLM QTGENLQCGQ GSVPMGSRNR ILQLMPQLSP TPSMMPSPNS HAAGFKGFGL EGVPEKRLTD PGLSSLSALS TQVANLPNTV QHMLLSDALT PQKKTSKRPS SSKKADSCTN SEGSSQPEEQ LKSPMAESLD GGCSSSSEDQ GERVRQLSGQ STSSDTTYKG GASEKAGSSP AQGAQNEPPR LNASPAAREE ATSPGAKDMP LSSDGNPKVN EKTVGVIVSR EAMTGRVEKP GGQDKGSQED DPAATQRPPS NGGAKETSHA SLPQPEPPGG GGSKGNKNGD NNSNHNGEGN GQSGHSAAGP GFTSRTEPSK SPGSLRYSYK DSFGSAVPRN VSGFPQYPTG QEKGDFTGHG ERKGRNEKFP SLLQEVLQGY HHHPDRRYSR STQEHQGMAG SLEGTTRPNV LVSQTNELAS RGLLNKSIGS LLENPHWGPW ERKSSSTAPE MKQINLTDYP IPRKFEIEPQ SSAHEPGGSL SERRSVICDI SPLRQIVRDP GAHSLGHMSA DTRIGRNDRL NPTLSQSVIL PGGLVSMETK LKSQSGQIKE EDFEQSKSQA SFNNKKSGDH CHPPSIKHES YRGNASPGAA THDSLSDYGP QDSRPTPMRR VPGRVGGREG MRGRSPSQYH DFAEKLKMSP GRSRGPGGDP HHMNPHMTFS ERANRSSLHT PFSPNSETLA SAYHANTRAH AYGDPNAGLN SQLHYKRQMY QQQPEEYKDW SSGSAQGVIA AAQHRQEGPR KSPRQQQFLD RVRSPLKNDK DGMMYGPPVG TYHDPSAQEA GRCLMSSDGL PNKGMELKHG SQKLQESCWD LSRQTSPAKS SGPPGMSSQK RYGPPHETDG HGLAEATQSS KPGSVMLRLP GQEDHSSQNP LIMRRRVRSF ISPIPSKRQS QDVKNSSTED KGRLLHSSKE GADKAFNSYA HLSHSQDIKS IPKRDSSKDL PSPDSRNCPA VTLTSPAKTK ILPPRKGRGL KLEAIVQKIT SPNIRRSASS NSAEAGGDTV TLDDILSLKS GPPEGGSVAV QDADIEKRKG EVASDLVSPA NQELHVEKPL PRSSEEWRGS VDDKVKTETH AETVTAGKEP PGAMTSTTSQ KPGSNQGRPD GSLGGTAPLI FPDSKNVPPV GILAPEANPK AEEKENDTVT ISPKQEGFPP KGYFPSGKKK GRPIGSVNKQ KKQQQPPPPP PQPPQIPEGS ADGEPKPKKQ RQRRERRKPG AQPRKRKTKQ AVPIVEPQEP EIKLKYATQP LDKTDAKNKS FYPYIHVVNK CELGAVCTII NAEEEEQTKL VRGRKGQRSL TPPPSSTESK ALPASSFMLQ GPVVTESSVM GHLVCCLCGK WASYRNMGDL FGPFYPQDYA ATLPKNPPPK RATEMQSKVK VRHKSASNGS KTDTEEEEEQ QQQQKEQRSL AAHPRFKRRH RSEDCGGGPR SLSRGLPCKK AATEGSSEKT VLDSKPSVPT TSEGGPELEL QIPELPLDSN EFWVHEGCIL WANGIYLVCG RLYGLQEALE IAREMKCSHC QEAGATLGCY NKGCSFRYHY PCAIDADCLL HEENFSVRCP KHKPPLPCPL PPLQNKTAKG SLSTEQSERG
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