About HMG domain-containing protein 4
HMG domain-containing protein 4 (HMGXB4) is a protein
from Homo sapiens identified by UniProt accession
Q9UGU5, 601 residues long.
MolForge cross-references it against 0 known binders and
31 disease associations.
Target properties
| Protein name | HMG domain-containing protein 4 |
|---|
| UniProt accession | Q9UGU5 |
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| Gene | HMGXB4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 601 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (31)
Diseases linked to this target (Open Targets).
- body height · score 0.32
- BMI-adjusted waist-hip ratio · score 0.32
- urate measurement · score 0.31
- bone density · score 0.31
- BMI-adjusted hip circumference · score 0.27
- platelet count · score 0.26
- low density lipoprotein cholesterol measurement · score 0.24
- total cholesterol measurement · score 0.23
- waist-hip ratio · score 0.23
- sitting height measurement · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UGU5-F1 | alphafold | PREDICTED | 55.66 | — |
Amino-acid sequence (601 residues)
MAYDDSVKKE DCFDGDHTFE DIGLAAGRSQ REKKRSYKDF LREEEEIAAQ VRNSSKKKLK DSELYFLGTD THKKKRKHSS DDYYYGDISS LESSQKKKKK SSPQSTDTAM DLLKAITSPL AAGSKPSKKT GEKSSGSSSH SESKKEHHRK KVSGSSGELP LEDGGSHKSK KMKPLYVNTE TLTLREPDGL KMKLILSPKE KGSSSVDEES FQYPSQQATV KKSSKKSARD EQGALLLGHE LQSFLKTARK KHKSSSDAHS SPGPEGCGSD ASQFAESHSA NLDLSGLEPI LVESDSSSGG ELEAGELVID DSYREIKKKK KSKKSKKKKD KEKHKEKRHS KSKRSLGLSA VPVGEVTVTS GPPPSIPYAG AAAPPLPLPG LHTDGHSEKK KKKEEKDKER ERGEKPKKKN MSAYQVFCKE YRVTIVADHP GIDFGELSKK LAEVWKQLPE KDKLIWKQKA QYLQHKQNKA EATTVKRKAS SSEGSMKVKA SSVGVLSPQK KSPPTTMLLP ASPAKAPETE PIDVAAHLQL LGESLSLIGH RLQETEGMVA VSGSLSVLLD SIICALGPLA CLTTQLPELN GCPKQVLSNT LDNIAYIMPG L
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