Protein NDRG3 (NDRG3)

About Protein NDRG3

Protein NDRG3 (NDRG3) is a protein from Homo sapiens identified by UniProt accession Q9UGV2, 375 residues long. MolForge cross-references it against 0 known binders and 137 disease associations.

Target properties

Protein name	Protein NDRG3
UniProt accession	Q9UGV2
Gene	NDRG3
Organism	Homo sapiens
Length	375 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (137)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.48
appendicular lean mass · score 0.25
body mass index · score 0.19
lysosomal storage disease · score 0.17
neoplasm · score 0.09
hepatocellular carcinoma · score 0.08
azoospermia · score 0.08
papillary thyroid carcinoma · score 0.07
male infertility with teratozoospermia due to single gene mutation · score 0.07
partial chromosome Y deletion · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UGV2-F1	alphafold	PREDICTED	81.08	—

Amino-acid sequence (375 residues)

MDELQDVQLT EIKPLLNDKN GTRNFQDFDC QEHDIETTHG VVHVTIRGLP KGNRPVILTY HDIGLNHKSC FNAFFNFEDM QEITQHFAVC HVDAPGQQEG APSFPTGYQY PTMDELAEML PPVLTHLSLK SIIGIGVGAG AYILSRFALN HPELVEGLVL INVDPCAKGW IDWAASKLSG LTTNVVDIIL AHHFGQEELQ ANLDLIQTYR MHIAQDINQD NLQLFLNSYN GRRDLEIERP ILGQNDNKSK TLKCSTLLVV GDNSPAVEAV VECNSRLNPI NTTLLKMADC GGLPQVVQPG KLTEAFKYFL QGMGYIPSAS MTRLARSRTH STSSSLGSGE SPFSRSVTSN QSDGTQESCE SPDVLDRHQT MEVSC

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards