About NADPH-dependent diflavin oxidoreductase 1
NADPH-dependent diflavin oxidoreductase 1 (NDOR1) is a protein
from Homo sapiens identified by UniProt accession
Q9UHB4, 597 residues long.
MolForge cross-references it against 0 known binders and
20 disease associations.
Target properties
| Protein name | NADPH-dependent diflavin oxidoreductase 1 |
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| UniProt accession | Q9UHB4 |
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| Gene | NDOR1 |
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| Organism | Homo sapiens |
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| Length | 597 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (20)
Diseases linked to this target (Open Targets).
- reticulocyte count · score 0.32
- mean corpuscular hemoglobin concentration · score 0.32
- mean corpuscular volume · score 0.31
- mean corpuscular hemoglobin · score 0.30
- erythrocyte count · score 0.30
- reticulocyte measurement · score 0.27
- red blood cell density measurement · score 0.26
- Immature Reticulocyte Fraction Measurement · score 0.25
- HbA1c measurement · score 0.23
- bilirubin measurement · score 0.20
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UHB4-F1 | alphafold | PREDICTED | 92.91 | — |
Amino-acid sequence (597 residues)
MPSPQLLVLF GSQTGTAQDV SERLGREARR RRLGCRVQAL DSYPVVNLIN EPLVIFVCAT TGQGDPPDNM KNFWRFIFRK NLPSTALCQM DFAVLGLGDS SYAKFNFVAK KLHRRLLQLG GSALLPVCLG DDQHELGPDA AVDPWLRDLW DRVLGLYPPP PGLTEIPPGV PLPSKFTLLF LQEAPSTGSE GQRVAHPGSQ EPPSESKPFL APMISNQRVT GPSHFQDVRL IEFDILGSGI SFAAGDVVLI QPSNSAAHVQ RFCQVLGLDP DQLFMLQPRE PDVSSPTRLP QPCSMRHLVS HYLDIASVPR RSFFELLACL SLHELEREKL LEFSSAQGQE ELFEYCNRPR RTILEVLCDF PHTAAAIPPD YLLDLIPVIR PRAFSIASSL LTHPSRLQIL VAVVQFQTRL KEPRRGLCSS WLASLDPGQG PVRVPLWVRP GSLAFPETPD TPVIMVGPGT GVAPFRAAIQ ERVAQGQTGN FLFFGCRWRD QDFYWEAEWQ ELEKRDCLTL IPAFSREQEQ KVYVQHRLRE LGSLVWELLD RQGAYFYLAG NAKSMPADVS EALMSIFQEE GGLCSPDAAA YLARLQQTRR FQTETWA
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