E3 ubiquitin-protein ligase makorin-1 (MKRN1)

About E3 ubiquitin-protein ligase makorin-1

E3 ubiquitin-protein ligase makorin-1 (MKRN1) is a protein from Homo sapiens identified by UniProt accession Q9UHC7, 482 residues long. MolForge cross-references it against 0 known binders and 87 disease associations.

Target properties

Protein name	E3 ubiquitin-protein ligase makorin-1
UniProt accession	Q9UHC7
Gene	MKRN1
Organism	Homo sapiens
Length	482 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (87)

Diseases linked to this target (Open Targets).

eosinophil count · score 0.31
body height · score 0.30
neurodegenerative disease · score 0.30
cystatin C measurement · score 0.25
Immature Reticulocyte Fraction Measurement · score 0.25
reticulocyte measurement · score 0.25
risky sexual behaviour measurement · score 0.25
risk-taking behaviour · score 0.24
age at first birth measurement · score 0.23
age at first sexual intercourse measurement · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UHC7-F1	alphafold	PREDICTED	66.18	—

Amino-acid sequence (482 residues)

MAEAATPGTT ATTSGAGAAA ATAAAASPTP IPTVTAPSLG AGGGGGGSDG SGGGWTKQVT CRYFMHGVCK EGDNCRYSHD LSDSPYSVVC KYFQRGYCIY GDRCRYEHSK PLKQEEATAT ELTTKSSLAA SSSLSSIVGP LVEMNTGEAE SRNSNFATVG AGSEDWVNAI EFVPGQPYCG RTAPSCTEAP LQGSVTKEES EKEQTAVETK KQLCPYAAVG ECRYGENCVY LHGDSCDMCG LQVLHPMDAA QRSQHIKSCI EAHEKDMELS FAVQRSKDMV CGICMEVVYE KANPSERRFG ILSNCNHTYC LKCIRKWRSA KQFESKIIKS CPECRITSNF VIPSEYWVEE KEEKQKLILK YKEAMSNKAC RYFDEGRGSC PFGGNCFYKH AYPDGRREEP QRQKVGTSSR YRAQRRNHFW ELIEERENSN PFDNDEEEVV TFELGEMLLM LLAAGGDDEL TDSEDEWDLF HDELEDFYDL DL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards