Cysteine and histidine-rich domain-containing…

About Cysteine and histidine-rich domain-containing protein 1

Cysteine and histidine-rich domain-containing protein 1 (CHORDC1) is a protein from Homo sapiens identified by UniProt accession Q9UHD1, 332 residues long. MolForge cross-references it against 0 known binders and 205 disease associations.

Target properties

Protein name	Cysteine and histidine-rich domain-containing protein 1
UniProt accession	Q9UHD1
Gene	CHORDC1
Organism	Homo sapiens
Length	332 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (205)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
body mass index · score 0.44
basophil percentage of leukocytes · score 0.34
mathematical ability · score 0.33
self reported educational attainment · score 0.30
uric acid measurement · score 0.28
visceral adipose tissue measurement · score 0.25
unipolar depression · score 0.24
body height · score 0.23
basophil count · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UHD1-F1	alphafold	PREDICTED	81.74	—

Amino-acid sequence (332 residues)

MALLCYNRGC GQRFDPETNS DDACTYHPGV PVFHDALKGW SCCKRRTTDF SDFLSIVGCT KGRHNSEKPP EPVKPEVKTT EKKELCELKP KFQEHIIQAP KPVEAIKRPS PDEPMTNLEL KISASLKQAL DKLKLSSGNE ENKKEEDNDE IKIGTSCKNG GCSKTYQGLE SLEEVCVYHS GVPIFHEGMK YWSCCRRKTS DFNTFLAQEG CTKGKHMWTK KDAGKKVVPC RHDWHQTGGE VTISVYAKNS LPELSRVEAN STLLNVHIVF EGEKEFDQNV KLWGVIDVKR SYVTMTATKI EITMRKAEPM QWASLELPAA KKQEKQKDAT TD

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)