About Serine/threonine-protein kinase TBK1
Serine/threonine-protein kinase TBK1 (TBK1) is a protein
from Homo sapiens identified by UniProt accession
Q9UHD2, 729 residues long.
MolForge cross-references it against 0 known binders and
454 disease associations.
Target properties
| Protein name | Serine/threonine-protein kinase TBK1 |
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| UniProt accession | Q9UHD2 |
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| Gene | TBK1 |
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| Organism | Homo sapiens |
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| Length | 729 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (14)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (454)
Diseases linked to this target (Open Targets).
- frontotemporal dementia and/or amyotrophic lateral sclerosis 4 · score 0.79
- Herpetic encephalitis · score 0.66
- amyotrophic lateral sclerosis · score 0.61
- COVID-19 · score 0.51
- Pick disease · score 0.39
- open-angle glaucoma · score 0.37
- Amyotrophic lateral sclerosis · score 0.37
- severe acute respiratory syndrome · score 0.37
- frontotemporal dementia with motor neuron disease · score 0.37
- motor neuron disease · score 0.37
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UHD2-F1 | alphafold | PREDICTED | 89.70 | — |
Amino-acid sequence (729 residues)
MQSTSNHLWL LSDILGQGAT ANVFRGRHKK TGDLFAIKVF NNISFLRPVD VQMREFEVLK KLNHKNIVKL FAIEEETTTR HKVLIMEFCP CGSLYTVLEE PSNAYGLPES EFLIVLRDVV GGMNHLRENG IVHRDIKPGN IMRVIGEDGQ SVYKLTDFGA ARELEDDEQF VSLYGTEEYL HPDMYERAVL RKDHQKKYGA TVDLWSIGVT FYHAATGSLP FRPFEGPRRN KEVMYKIITG KPSGAISGVQ KAENGPIDWS GDMPVSCSLS RGLQVLLTPV LANILEADQE KCWGFDQFFA ETSDILHRMV IHVFSLQQMT AHKIYIHSYN TATIFHELVY KQTKIISSNQ ELIYEGRRLV LEPGRLAQHF PKTTEENPIF VVSREPLNTI GLIYEKISLP KVHPRYDLDG DASMAKAITG VVCYACRIAS TLLLYQELMR KGIRWLIELI KDDYNETVHK KTEVVITLDF CIRNIEKTVK VYEKLMKINL EAAELGEISD IHTKLLRLSS SQGTIETSLQ DIDSRLSPGG SLADAWAHQE GTHPKDRNVE KLQVLLNCMT EIYYQFKKDK AERRLAYNEE QIHKFDKQKL YYHATKAMTH FTDECVKKYE AFLNKSEEWI RKMLHLRKQL LSLTNQCFDI EEEVSKYQEY TNELQETLPQ KMFTASSGIK HTMTPIYPSS NTLVEMTLGM KKLKEEMEGV VKELAENNHI LERFGSLTMD GGLRNVDCL
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