About Septin-9
Septin-9 (SEPTIN9) is a protein
from Homo sapiens identified by UniProt accession
Q9UHD8, 586 residues long.
MolForge cross-references it against 0 known binders and
258 disease associations.
Target properties
| Protein name | Septin-9 |
|---|
| UniProt accession | Q9UHD8 |
|---|
| Gene | SEPTIN9 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 586 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (1)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (258)
Diseases linked to this target (Open Targets).
- neuralgic amyotrophy · score 0.56
- heel bone mineral density · score 0.49
- refractive error measurement · score 0.49
- reticulocyte count · score 0.48
- systolic blood pressure · score 0.47
- serum gamma-glutamyl transferase measurement · score 0.45
- body height · score 0.44
- genetic disorder · score 0.41
- reticulocyte measurement · score 0.41
- intraocular pressure measurement · score 0.40
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UHD8-F1 | alphafold | PREDICTED | 66.35 | — |
Amino-acid sequence (586 residues)
MKKSYSGGTR TSSGRLRRLG DSSGPALKRS FEVEEVETPN STPPRRVQTP LLRATVASST QKFQDLGVKN SEPSARHVDS LSQRSPKASL RRVELSGPKA AEPVSRRTEL SIDISSKQVE NAGAIGPSRF GLKRAEVLGH KTPEPAPRRT EITIVKPQES AHRRMEPPAS KVPEVPTAPA TDAAPKRVEI QMPKPAEAPT APSPAQTLEN SEPAPVSQLQ SRLEPKPQPP VAEATPRSQE ATEAAPSCVG DMADTPRDAG LKQAPASRNE KAPVDFGYVG IDSILEQMRR KAMKQGFEFN IMVVGQSGLG KSTLINTLFK SKISRKSVQP TSEERIPKTI EIKSITHDIE EKGVRMKLTV IDTPGFGDHI NNENCWQPIM KFINDQYEKY LQEEVNINRK KRIPDTRVHC CLYFIPATGH SLRPLDIEFM KRLSKVVNIV PVIAKADTLT LEERVHFKQR ITADLLSNGI DVYPQKEFDE DSEDRLVNEK FREMIPFAVV GSDHEYQVNG KRILGRKTKW GTIEVENTTH CEFAYLRDLL IRTHMQNIKD ITSSIHFEAY RVKRLNEGSS AMANGMEEKE PEAPEM
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