Ena/VASP-like protein (EVL)

About Ena/VASP-like protein

Ena/VASP-like protein (EVL) is a protein from Homo sapiens identified by UniProt accession Q9UI08, 416 residues long. MolForge cross-references it against 0 known binders and 130 disease associations.

Target properties

Protein name	Ena/VASP-like protein
UniProt accession	Q9UI08
Gene	EVL
Organism	Homo sapiens
Length	416 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (130)

Diseases linked to this target (Open Targets).

white matter hyperintensity measurement · score 0.20
mean corpuscular hemoglobin · score 0.19
breast adenocarcinoma · score 0.18
systolic blood pressure · score 0.16
mean corpuscular hemoglobin concentration · score 0.15
heel bone mineral density · score 0.10
mean corpuscular volume · score 0.10
Heterotaxia · score 0.07
cortical thickness · score 0.06
MODY · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UI08-F1	alphafold	PREDICTED	69.18	—

Amino-acid sequence (416 residues)

MSEQSICQAR ASVMVYDDTS KKWVPIKPGQ QGFSRINIYH NTASNTFRVV GVKLQDQQVV INYSIVKGLK YNQATPTFHQ WRDARQVYGL NFASKEEATT FSNAMLFALN IMNSQEGGPS SQRQVQNGPS PDEMDIQRRQ VMEQHQQQRQ ESLERRTSAT GPILPPGHPS SAASAPVSCS GPPPPPPPPV PPPPTGATPP PPPPLPAGGA QGSSHDESSM SGLAAAIAGA KLRRVQRPED ASGGSSPSGT SKSDANRASS GGGGGGLMEE MNKLLAKRRK AASQSDKPAE KKEDESQMED PSTSPSPGTR AASQPPNSSE AGRKPWERSN SVEKPVSSIL SRTPSVAKSP EAKSPLQSQP HSRMKPAGSV NDMALDAFDL DRMKQEILEE VVRELHKVKE EIIDAIRQEL SGISTT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards