NADH dehydrogenase [ubiquinone] 1 alpha subcomplex…

About NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NDUFA12) is a protein from Homo sapiens identified by UniProt accession Q9UI09, 145 residues long. MolForge cross-references it against 0 known binders and 246 disease associations.

Target properties

Protein name	NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12
UniProt accession	Q9UI09
Gene	NDUFA12
Organism	Homo sapiens
Length	145 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (246)

Diseases linked to this target (Open Targets).

type 2 diabetes mellitus · score 0.61
diabetes mellitus · score 0.60
polycystic ovary syndrome · score 0.60
type 1 diabetes mellitus · score 0.58
gestational diabetes · score 0.58
obesity · score 0.57
prediabetes syndrome · score 0.56
schizophrenia · score 0.55
insulin resistance · score 0.55
metabolic syndrome · score 0.53

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UI09-F1	alphafold	PREDICTED	95.92	—

Amino-acid sequence (145 residues)

MELVQVLKRG LQQITGHGGL RGYLRVFFRT NDAKVGTLVG EDKYGNKYYE DNKQFFGRHR WVVYTTEMNG KNTFWDVDGS MVPPEWHRWL HSMTDDPPTT KPLTARKFIW TNHKFNVTGT PEQYVPYSTT RKKIQEWIPP STPYK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 12 (NDUFA12)