About Translation initiation factor eIF2B subunit delta
Translation initiation factor eIF2B subunit delta (EIF2B4) is a protein
from Homo sapiens identified by UniProt accession
Q9UI10, 523 residues long.
MolForge cross-references it against 0 known binders and
86 disease associations.
Target properties
| Protein name | Translation initiation factor eIF2B subunit delta |
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| UniProt accession | Q9UI10 |
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| Gene | EIF2B4 |
|---|
| Organism | Homo sapiens |
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| Length | 523 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (86)
Diseases linked to this target (Open Targets).
- CACH syndrome · score 0.72
- leukoencephalopathy with vanishing white matter 1 · score 0.64
- ovarioleukodystrophy · score 0.61
- leukoencephalopathy with vanishing white matter · score 0.55
- late infantile CACH syndrome · score 0.37
- juvenile or adult CACH syndrome · score 0.37
- congenital or early infantile CACH syndrome · score 0.37
- genetic disorder · score 0.19
- mean corpuscular hemoglobin concentration · score 0.14
- forced expiratory volume · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UI10-F1 | alphafold | PREDICTED | 76.50 | — |
Amino-acid sequence (523 residues)
MAAVAVAVRE DSGSGMKAEL PPGPGAVGRE MTKEEKLQLR KEKKQQKKKR KEEKGAEPET GSAVSAAQCQ VGPTRELPES GIQLGTPREK VPAGRSKAEL RAERRAKQEA ERALKQARKG EQGGPPPKAS PSTAGETPSG VKRLPEYPQV DDLLLRRLVK KPERQQVPTR KDYGSKVSLF SHLPQYSRQN SLTQFMSIPS SVIHPAMVRL GLQYSQGLVS GSNARCIALL RALQQVIQDY TTPPNEELSR DLVNKLKPYM SFLTQCRPLS ASMHNAIKFL NKEITSVGSS KREEEAKSEL RAAIDRYVQE KIVLAAQAIS RFAYQKISNG DVILVYGCSS LVSRILQEAW TEGRRFRVVV VDSRPWLEGR HTLRSLVHAG VPASYLLIPA ASYVLPEVSK VLLGAHALLA NGSVMSRVGT AQLALVARAH NVPVLVCCET YKFCERVQTD AFVSNELDDP DDLQCKRGEH VALANWQNHA SLRLLNLVYD VTPPELVDLV ITELGMIPCS SVPVVLRVKS SDQ
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