V-type proton ATPase subunit H (ATP6V1H)

About V-type proton ATPase subunit H

V-type proton ATPase subunit H (ATP6V1H) is a protein from Homo sapiens identified by UniProt accession Q9UI12, 483 residues long. MolForge cross-references it against 0 known binders and 86 disease associations.

Target properties

Protein name	V-type proton ATPase subunit H
UniProt accession	Q9UI12
Gene	ATP6V1H
Organism	Homo sapiens
Length	483 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (86)

Diseases linked to this target (Open Targets).

HIV infection · score 0.55
neurodegenerative disease · score 0.54
tuberculosis · score 0.37
breast adenocarcinoma · score 0.21
beta-secretase 1 measurement · score 0.15
age at first sexual intercourse measurement · score 0.08
age-related macular degeneration · score 0.08
X-linked retinal dysplasia · score 0.06
autosomal dominant hypophosphatemic rickets · score 0.06
severe early-childhood-onset retinal dystrophy · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UI12-F1	alphafold	PREDICTED	87.33	—

Amino-acid sequence (483 residues)

MTKMDIRGAV DAAVPTNIIA AKAAEVRANK VNWQSYLQGQ MISAEDCEFI QRFEMKRSPE EKQEMLQTEG SQCAKTFINL MTHICKEQTV QYILTMVDDM LQENHQRVSI FFDYARCSKN TAWPYFLPML NRQDPFTVHM AARIIAKLAA WGKELMEGSD LNYYFNWIKT QLSSQKLRGS GVAVETGTVS SSDSSQYVQC VAGCLQLMLR VNEYRFAWVE ADGVNCIMGV LSNKCGFQLQ YQMIFSIWLL AFSPQMCEHL RRYNIIPVLS DILQESVKEK VTRIILAAFR NFLEKSTERE TRQEYALAMI QCKVLKQLEN LEQQKYDDED ISEDIKFLLE KLGESVQDLS SFDEYSSELK SGRLEWSPVH KSEKFWRENA VRLNEKNYEL LKILTKLLEV SDDPQVLAVA AHDVGEYVRH YPRGKRVIEQ LGGKQLVMNH MHHEDQQVRY NALLAVQKLM VHNWEYLGKQ LQSEQPQTAA ARS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards