Multifunctional methyltransferase subunit…

About Multifunctional methyltransferase subunit TRM112-like protein

Multifunctional methyltransferase subunit TRM112-like protein (TRMT112) is a protein from Homo sapiens identified by UniProt accession Q9UI30, 125 residues long. MolForge cross-references it against 0 known binders and 41 disease associations.

Target properties

Protein name	Multifunctional methyltransferase subunit TRM112-like protein
UniProt accession	Q9UI30
Gene	TRMT112
Organism	Homo sapiens
Length	125 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (41)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.17
endometrial cancer · score 0.13
serum metabolite measurement · score 0.10
parental genotype effect measurement · score 0.06
birth weight · score 0.06
eosinophil count · score 0.05
hematocrit · score 0.05
eosinophil percentage of leukocytes · score 0.04
neoplasm · score 0.04
heel bone mineral density · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UI30-F1	alphafold	PREDICTED	92.12	—

Amino-acid sequence (125 residues)

MKLLTHNLLS SHVRGVGSRG FPLRLQATEV RICPVEFNPN FVARMIPKVE WSAFLEAADN LRLIQVPKGP VEGYEENEEF LRTMHHLLLE VEVIEGTLQC PESGRMFPIS RGIPNMLLSE EETES

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Multifunctional methyltransferase subunit TRM112-like protein (TRMT112)