About Glutaminase liver isoform, mitochondrial
Glutaminase liver isoform, mitochondrial (GLS2) is a protein
from Homo sapiens identified by UniProt accession
Q9UI32, 602 residues long.
MolForge cross-references it against 0 known binders and
210 disease associations.
Target properties
| Protein name | Glutaminase liver isoform, mitochondrial |
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| UniProt accession | Q9UI32 |
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| Gene | GLS2 |
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| Organism | Homo sapiens |
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| Length | 602 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (210)
Diseases linked to this target (Open Targets).
- glutamine measurement · score 0.55
- serum urea measurement · score 0.26
- triglyceride measurement · score 0.25
- amino acid measurement · score 0.24
- serum metabolite measurement · score 0.23
- blood metabolite measurement · score 0.22
- C-reactive protein measurement · score 0.22
- serum albumin measurement · score 0.21
- urate measurement · score 0.21
- glomerular filtration rate · score 0.21
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UI32-F1 | alphafold | PREDICTED | 85.48 | — |
Amino-acid sequence (602 residues)
MRSMKALQKA LSRAGSHCGR GGWGHPSRSP LLGGGVRHHL SEAAAQGRET PHSHQPQHQD HDSSESGMLS RLGDLLFYTI AEGQERIPIH KFTTALKATG LQTSDPRLRD CMSEMHRVVQ ESSSGGLLDR DLFRKCVSSN IVLLTQAFRK KFVIPDFEEF TGHVDRIFED VKELTGGKVA AYIPQLAKSN PDLWGVSLCT VDGQRHSVGH TKIPFCLQSC VKPLTYAISI STLGTDYVHK FVGKEPSGLR YNKLSLNEEG IPHNPMVNAG AIVVSSLIKM DCNKAEKFDF VLQYLNKMAG NEYMGFSNAT FQSEKETGDR NYAIGYYLKE KKCFPKGVDM MAALDLYFQL CSVEVTCESG SVMAATLANG GICPITGESV LSAEAVRNTL SLMHSCGMYD FSGQFAFHVG LPAKSAVSGA ILLVVPNVMG MMCLSPPLDK LGNSHRGTSF CQKLVSLFNF HNYDNLRHCA RKLDPRREGA EIRNKTVVNL LFAAYSGDVS ALRRFALSAM DMEQKDYDSR TALHVAAAEG HIEVVKFLIE ACKVNPFAKD RWGNIPLDDA VQFNHLEVVK LLQDYQDSYT LSETQAEAAA EALSKENLES MV
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