About Dachshund homolog 1
Dachshund homolog 1 (DACH1) is a protein
from Homo sapiens identified by UniProt accession
Q9UI36, 758 residues long.
MolForge cross-references it against 0 known binders and
211 disease associations.
Target properties
| Protein name | Dachshund homolog 1 |
|---|
| UniProt accession | Q9UI36 |
|---|
| Gene | DACH1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 758 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (211)
Diseases linked to this target (Open Targets).
- monocyte count · score 0.47
- neurodegenerative disease · score 0.46
- glomerular filtration rate · score 0.45
- lymphocyte count · score 0.44
- platelet count · score 0.44
- creatinine measurement · score 0.43
- urate measurement · score 0.43
- monocyte percentage of leukocytes · score 0.43
- blood urea nitrogen measurement · score 0.41
- platelet crit · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UI36-F1 | alphafold | PREDICTED | 57.16 | — |
Amino-acid sequence (758 residues)
MAVPAALIPP TQLVPPQPPI STSASSSGTT TSTSSATSSP APSIGPPASS GPTLFRPEPI ASAAAAAATV TSTGGGGGGG GSGGGGGSSG NGGGGGGGGG GSNCNPNLAA ASNGSGGGGG GISAGGGVAS STPINASTGS SSSSSSSSSS SSSSSSSSSS SSSCGPLPGK PVYSTPSPVE NTPQNNECKM VDLRGAKVAS FTVEGCELIC LPQAFDLFLK HLVGGLHTVY TKLKRLEITP VVCNVEQVRI LRGLGAIQPG VNRCKLISRK DFETLYNDCT NASSRPGRPP KRTQSVTSPE NSHIMPHSVP GLMSPGIIPP TGLTAAAAAA AAATNAAIAE AMKVKKIKLE AMSNYHASNN QHGADSENGD MNSSVGSSDG SWDKETLPSS PSQGPQASIT HPRMPGARSL PLSHPLNHLQ QSHLLPNGLE LPFMMMPHPL IPVSLPPASV TMAMSQMNHL STIANMAAAA QVQSPPSRVE TSVIKERVPD SPSPAPSLEE GRRPGSHPSS HRSSSVSSSP ARTESSSDRI PVHQNGLSMN QMLMGLSPNV LPGPKEGDLA GHDMGHESKR MHIEKDETPL STPTARDSLD KLSLTGHGQP LPPGFPSPFL FPDGLSSIET LLTNIQGLLK VAIDNARAQE KQVQLEKTEL KMDFLREREL RETLEKQLAM EQKNRAIVQK RLKKEKKAKR KLQEALEFET KRREQAEQTL KQAASTDSLR VLNDSLTPEI EADRSGGRTD AERTIQDGRL YLKTTVMY
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