Probable threonine protease PRSS50 (PRSS50)

About Probable threonine protease PRSS50

Probable threonine protease PRSS50 (PRSS50) is a protein from Homo sapiens identified by UniProt accession Q9UI38, 385 residues long. MolForge cross-references it against 0 known binders and 129 disease associations.

Target properties

Protein name	Probable threonine protease PRSS50
UniProt accession	Q9UI38
Gene	PRSS50
Organism	Homo sapiens
Length	385 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (129)

Diseases linked to this target (Open Targets).

neoplasm · score 0.11
azoospermia · score 0.10
colorectal carcinoma · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.09
hepatocellular carcinoma · score 0.09
colitis · score 0.07
partial chromosome Y deletion · score 0.07
spermatogenic failure 72 · score 0.07
spermatogenic failure 46 · score 0.07
spermatogenic failure 18 · score 0.07

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UI38-F1	alphafold	PREDICTED	74.36	—

Amino-acid sequence (385 residues)

MGRWCQTVAR GQRPRTSAPS RAGALLLLLL LLRSAGCWGA GEAPGALSTA DPADQSVQCV PKATCPSSRP RLLWQTPTTQ TLPSTTMETQ FPVSEGKVDP YRSCGFSYEQ DPTLRDPEAV ARRWPWMVSV RANGTHICAG TIIASQWVLT VAHCLIWRDV IYSVRVGSPW IDQMTQTASD VPVLQVIMHS RYRAQRFWSW VGQANDIGLL KLKQELKYSN YVRPICLPGT DYVLKDHSRC TVTGWGLSKA DGMWPQFRTI QEKEVIILNN KECDNFYHNF TKIPTLVQII KSQMMCAEDT HREKFCYELT GEPLVCSMEG TWYLVGLVSW GAGCQKSEAP PIYLQVSSYQ HWIWDCLNGQ ALALPAPSRT LLLALPLPLS LLAAL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards