About Sodium/potassium/calcium exchanger 2
Sodium/potassium/calcium exchanger 2 (SLC24A2) is a protein
from Homo sapiens identified by UniProt accession
Q9UI40, 661 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Sodium/potassium/calcium exchanger 2 |
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| UniProt accession | Q9UI40 |
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| Gene | SLC24A2 |
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| Organism | Homo sapiens |
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| Length | 661 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (47)
Diseases linked to this target (Open Targets).
- risk-taking behaviour · score 0.42
- mathematical ability · score 0.32
- protein measurement · score 0.27
- adolescent idiopathic scoliosis · score 0.24
- blood protein measurement · score 0.18
- Abnormality of refraction · score 0.16
- arterial stiffness measurement · score 0.12
- type 2 diabetes mellitus · score 0.09
- monocyte count · score 0.06
- atrial fibrillation · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UI40-F1 | alphafold | PREDICTED | 67.27 | — |
Amino-acid sequence (661 residues)
MDLQQSTTIT SLEKWCLDES LSGCRRHYSV KKKLKLIRVL GLFMGLVAIS TVSFSISAFS ETDTQSTGEA SVVSGPRVAQ GYHQRTLLDL NDKILDYTPQ PPLSKEGESE NSTDHAQGDY PKDIFSLEER RKGAIILHVI GMIYMFIALA IVCDEFFVPS LTVITEKLGI SDDVAGATFM AAGGSAPELF TSLIGVFIAH SNVGIGTIVG SAVFNILFVI GMCALFSREI LNLTWWPLFR DVSFYIVDLI MLIIFFLDNV IMWWESLLLL TAYFCYVVFM KFNVQVEKWV KQMINRNKVV KVTAPEAQAK PSAARDKDEP TLPAKPRLQR GGSSASLHNS LMRNSIFQLM IHTLDPLAEE LGSYGKLKYY DTMTEEGRFR EKASILHKIA KKKCHVDENE RQNGAANHVE KIELPNSTST DVEMTPSSDA SEPVQNGNLS HNIEGAEAQT ADEEEDQPLS LAWPSETRKQ VTFLIVFPIV FPLWITLPDV RKPSSRKFFP ITFFGSITWI AVFSYLMVWW AHQVGETIGI SEEIMGLTIL AAGTSIPDLI TSVIVARKGL GDMAVSSSVG SNIFDITVGL PLPWLLYTVI HRFQPVAVSS NGLFCAIVLL FIMLLFVILS IALCKWRMNK ILGFIMFGLY FVFLVVSVLL EDRILTCPVS I
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