Catenin alpha-3 (CTNNA3)

About Catenin alpha-3

Catenin alpha-3 (CTNNA3) is a protein from Homo sapiens identified by UniProt accession Q9UI47, 895 residues long. MolForge cross-references it against 0 known binders and 278 disease associations.

Target properties

Protein name	Catenin alpha-3
UniProt accession	Q9UI47
Gene	CTNNA3
Organism	Homo sapiens
Length	895 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (278)

Diseases linked to this target (Open Targets).

Arrhythmogenic right ventricular dysplasia · score 0.58
familial isolated arrhythmogenic right ventricular dysplasia · score 0.48
electrocardiography · score 0.43
self reported educational attainment · score 0.42
familial isolated arrhythmogenic ventricular dysplasia, biventricular form · score 0.37
familial isolated arrhythmogenic ventricular dysplasia, left dominant form · score 0.37
familial isolated arrhythmogenic ventricular dysplasia, right dominant form · score 0.37
protein measurement · score 0.36
atrial fibrillation · score 0.34
cognitive function measurement · score 0.34

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UI47-F1	alphafold	PREDICTED	81.64	—

Amino-acid sequence (895 residues)

MSAETPITLN IDPQDLQVQT FTVEKLLEPL IIQVTTLVNC PQNPSSRKKG RSKRASVLLA SVEEATWNLL DKGEKIAQEA TVLKDELTAS LEEVRKESEA LKVSAERFTD DPCFLPKREA VVQAARALLA AVTRLLILAD MIDVMCLLQH VSAFQRTFES LKNVANKSDL QKTYQKLGKE LENLDYLAFK RQQDLKSPNQ RDEIAGARAS LKENSPLLHS ICSACLEHSD VASLKASKDT VCEEIQNALN VISNASQGIQ NMTTPPEPQA ATLGSALDEL ENLIVLNPLT VTEEEIRPSL EKRLEAIISG AALLADSSCT RDLHRERIIA ECNAIRQALQ DLLSEYMNNA GKKERSNTLN IALDNMCKKT RDLRRQLRKA IIDHVSDSFL DTTVPLLVLI EAAKNGREKE IKEYAAIFHE HTSRLVEVAN LACSMSTNED GIKIVKIAAN HLETLCPQII NAALALAARP KSQAVKNTME MYKRTWENHI HVLTEAVDDI TSIDDFLAVS ESHILEDVNK CIIALRDQDA DNLDRAAGAI RGRAARVAHI VTGEMDSYEP GAYTEGVMRN VNFLTSTVIP EFVTQVNVAL EALSKSSLNV LDDNQFVDIS KKIYDTIHDI RCSVMMIRTP EELEDVSDLE EEHEVRSHTS IQTEGKTDRA KMTQLPEAEK EKIAEQVADF KKVKSKLDAE IEIWDDTSND IIVLAKNMCM IMMEMTDFTR GKGPLKHTTD VIYAAKMISE SGSRMDVLAR QIANQCPDPS CKQDLLAYLE QIKFYSHQLK ICSQVKAEIQ NLGGELIMSA LDSVTSLIQA AKNLMNAVVQ TVKMSYIAST KIIRIQSPAG PRHPVVMWRM KAPAKKPLIK REKPEETCAA VRRGSAKKKI HPLQVMSEFR GRQIY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards