Mitotic spindle assembly checkpoint protein MAD2B…

About Mitotic spindle assembly checkpoint protein MAD2B

Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2) is a protein from Homo sapiens identified by UniProt accession Q9UI95, 211 residues long. MolForge cross-references it against 0 known binders and 234 disease associations.

Target properties

Protein name	Mitotic spindle assembly checkpoint protein MAD2B
UniProt accession	Q9UI95
Gene	MAD2L2
Organism	Homo sapiens
Length	211 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (234)

Diseases linked to this target (Open Targets).

Fanconi anemia complementation group V · score 0.57
Fanconi anemia · score 0.56
myelodysplastic syndrome · score 0.46
acute myeloid leukemia · score 0.46
breast adenocarcinoma · score 0.18
cancer · score 0.09
azoospermia · score 0.09
neoplasm · score 0.09
partial chromosome Y deletion · score 0.08
male infertility with teratozoospermia due to single gene mutation · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UI95-F1	alphafold	PREDICTED	90.39	—

Amino-acid sequence (211 residues)

MTTLTRQDLN FGQVVADVLC EFLEVAVHLI LYVREVYPVG IFQKRKKYNV PVQMSCHPEL NQYIQDTLHC VKPLLEKNDV EKVVVVILDK EHRPVEKFVF EITQPPLLSI SSDSLLSHVE QLLRAFILKI SVCDAVLDHN PPGCTFTVLV HTREAATRNM EKIQVIKDFP WILADEQDVH MHDPRLIPLK TMTSDILKMQ LYVEERAHKG S

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Mitotic spindle assembly checkpoint protein MAD2B (MAD2L2)