Leucine carboxyl methyltransferase 1 (LCMT1)

About Leucine carboxyl methyltransferase 1

Leucine carboxyl methyltransferase 1 (LCMT1) is a protein from Homo sapiens identified by UniProt accession Q9UIC8, 334 residues long. MolForge cross-references it against 0 known binders and 58 disease associations.

Target properties

Protein name	Leucine carboxyl methyltransferase 1
UniProt accession	Q9UIC8
Gene	LCMT1
Organism	Homo sapiens
Length	334 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (58)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
lysosomal storage disease · score 0.33
Alzheimer disease · score 0.33
Parkinson disease · score 0.33
multiple sclerosis · score 0.33
PHF-tau measurement · score 0.30
MODY · score 0.08
hepatocellular carcinoma · score 0.08
type 2 diabetes mellitus · score 0.07
hyperinsulinism due to INSR deficiency · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UIC8-F1	alphafold	PREDICTED	93.41	—

Amino-acid sequence (334 residues)

MATRQRESSI TSCCSTSSCD ADDEGVRGTC EDASLCKRFA VSIGYWHDPY IQHFVRLSKE RKAPEINRGY FARVHGVSQL IKAFLRKTEC HCQIVNLGAG MDTTFWRLKD EDLLPSKYFE VDFPMIVTRK LHSIKCKPPL SSPILELHSE DTLQMDGHIL DSKRYAVIGA DLRDLSELEE KLKKCNMNTQ LPTLLIAECV LVYMTPEQSA NLLKWAANSF ERAMFINYEQ VNMGDRFGQI MIENLRRRQC DLAGVETCKS LESQKERLLS NGWETASAVD MMELYNRLPR AEVSRIESLE FLDEMELLEQ LMRHYCLCWA TKGGNELGLK EITY

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards