About Vacuolar protein sorting-associated protein 51 homolog
Vacuolar protein sorting-associated protein 51 homolog (VPS51) is a protein
from Homo sapiens identified by UniProt accession
Q9UID3, 782 residues long.
MolForge cross-references it against 0 known binders and
30 disease associations.
Target properties
| Protein name | Vacuolar protein sorting-associated protein 51 homolog |
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| UniProt accession | Q9UID3 |
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| Gene | VPS51 |
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| Organism | Homo sapiens |
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| Length | 782 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (30)
Diseases linked to this target (Open Targets).
- pontocerebellar hypoplasia type 13 · score 0.61
- neurodegenerative disease · score 0.53
- visual perception measurement · score 0.16
- high density lipoprotein cholesterol measurement · score 0.07
- Crigler-Najjar syndrome type 2 · score 0.04
- transient familial neonatal hyperbilirubinemia · score 0.04
- gluthathione peroxidase deficiency · score 0.03
- Rotor syndrome · score 0.03
- hypercholanemia, familial, 2 · score 0.03
- otosclerosis · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UID3-F1 | alphafold | PREDICTED | 80.35 | — |
Amino-acid sequence (782 residues)
MAAAAAAGPS PGSGPGDSPE GPEGEAPERR RKAHGMLKLY YGLSEGEAAG RPAGPDPLDP TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL DSDMQTLVYE NYNKFISATD TIRKMKNDFR KMEDEMDRLA TNMAVITDFS ARISATLQDR HERITKLAGV HALLRKLQFL FELPSRLTKC VELGAYGQAV RYQGRAQAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR FREGGSGAPE QAECVELLLA LGEPAEELCE EFLAHARGRL EKELRNLEAE LGPSPPAPDV LEFTDHGGSG FVGGLCQVAA AYQELFAAQG PAGAEKLAAF ARQLGSRYFA LVERRLAQEQ GGGDNSLLVR ALDRFHRRLR APGALLAAAG LADAATEIVE RVARERLGHH LQGLRAAFLG CLTDVRQALA APRVAGKEGP GLAELLANVA SSILSHIKAS LAAVHLFTAK EVSFSNKPYF RGEFCSQGVR EGLIVGFVHS MCQTAQSFCD SPGEKGGATP PALLLLLSRL CLDYETATIS YILTLTDEQF LVQDQFPVTP VSTLCAEARE TARRLLTHYV KVQGLVISQM LRKSVETRDW LSTLEPRNVR AVMKRVVEDT TAIDVQVGLL YEEGVRKAQS SDSSKRTFSV YSSSRQQGRY APSYTPSAPM DTNLLSNIQK LFSERIDVFS PVEFNKVSVL TGIIKISLKT LLECVRLRTF GRFGLQQVQV DCHFLQLYLW RFVADEELVH LLLDEVVASA ALRCPDPVPM EPSVVEVICE RG
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