Tektin-2 (TEKT2)

About Tektin-2

Tektin-2 (TEKT2) is a protein from Homo sapiens identified by UniProt accession Q9UIF3, 430 residues long. MolForge cross-references it against 0 known binders and 82 disease associations.

Target properties

Protein name	Tektin-2
UniProt accession	Q9UIF3
Gene	TEKT2
Organism	Homo sapiens
Length	430 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (82)

Diseases linked to this target (Open Targets).

azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.06
central corneal thickness · score 0.05
spermatogenic failure 65 · score 0.05
spermatogenic failure 72 · score 0.05
spermatogenic failure 56 · score 0.05
spermatogenic failure 46 · score 0.05
spermatogenic failure 27 · score 0.05
spermatogenic failure 18 · score 0.05
spermatogenic failure 42 · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UIF3-F1	alphafold	PREDICTED	91.28	—

Amino-acid sequence (430 residues)

MATLSVKPSR RFQLPDWHTN SYLLSTNAQL QRDASHQIRQ EARVLRNETN NQTIWDEHDN RTRLVERIDT VNRWKEMLDK CLTDLDAEID ALTQMKESAE QNLQAKNLPL DVAIECLTLR ESRRDIDVVK DPVEDELHKE VEVIEATKKA LQQKVSQAFE QLCLLQEVQQ QLNSDHRGKM ETLEIDRGCL SLNLRSPNIS LKVDPTRVPD GSTTLQQWDD FSRFNKDRAE AEMKAATELR EATALTIAET NNELEAQRVA TEFAFRKRLR EMEKVYSELK WQEKNTLEEI AELQEDIRHL EEDLRTKLLS LKLSHTRLEA RTYRPNVELC RDQAQYGLTD EVHQLEATIA ALKQKLAQAQ DALDALCKHL ARLQADIACK ANSMLLDTKC MDTRRKLTVP AERFVPEVDT FTRTTNSTLS PLKSCQLELA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards