Krueppel-like factor 15 (KLF15)

About Krueppel-like factor 15

Krueppel-like factor 15 (KLF15) is a protein from Homo sapiens identified by UniProt accession Q9UIH9, 416 residues long. MolForge cross-references it against 0 known binders and 211 disease associations.

Target properties

Protein name	Krueppel-like factor 15
UniProt accession	Q9UIH9
Gene	KLF15
Organism	Homo sapiens
Length	416 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (211)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.45
hair shape measurement · score 0.43
urate measurement · score 0.37
alopecia · score 0.35
insomnia · score 0.30
total blood protein measurement · score 0.30
balding measurement · score 0.29
androgenetic alopecia · score 0.28
serum gamma-glutamyl transferase measurement · score 0.27
serum alanine aminotransferase measurement · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UIH9-F1	alphafold	PREDICTED	50.32	—

Amino-acid sequence (416 residues)

MVDHLLPVDE NFSSPKCPVG YLGDRLVGRR AYHMLPSPVS EDDSDASSPC SCSSPDSQAL CSCYGGGLGT ESQDSILDFL LSQATLGSGG GSGSSIGASS GPVAWGPWRR AAAPVKGEHF CLPEFPLGDP DDVPRPFQPT LEEIEEFLEE NMEPGVKEVP EGNSKDLDAC SQLSAGPHKS HLHPGSSGRE RCSPPPGGAS AGGAQGPGGG PTPDGPIPVL LQIQPVPVKQ ESGTGPASPG QAPENVKVAQ LLVNIQGQTF ALVPQVVPSS NLNLPSKFVR IAPVPIAAKP VGSGPLGPGP AGLLMGQKFP KNPAAELIKM HKCTFPGCSK MYTKSSHLKA HLRRHTGEKP FACTWPGCGW RFSRSDELSR HRRSHSGVKP YQCPVCEKKF ARSDHLSKHI KVHRFPRSSR SVRSVN

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards