About GTP:AMP phosphotransferase AK3, mitochondrial
GTP:AMP phosphotransferase AK3, mitochondrial (AK3) is a protein
from Homo sapiens identified by UniProt accession
Q9UIJ7, 227 residues long.
MolForge cross-references it against 0 known binders and
37 disease associations.
Target properties
| Protein name | GTP:AMP phosphotransferase AK3, mitochondrial |
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| UniProt accession | Q9UIJ7 |
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| Gene | AK3 |
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| Organism | Homo sapiens |
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| Length | 227 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (37)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.39
- body height · score 0.35
- platelet count · score 0.29
- lymphocyte percentage of leukocytes · score 0.26
- neutrophil percentage of leukocytes · score 0.23
- sitting height measurement · score 0.23
- platelet crit · score 0.20
- leukocyte count · score 0.19
- mean platelet volume · score 0.19
- ovarian cancer · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UIJ7-F1 | alphafold | PREDICTED | 91.37 | — |
Amino-acid sequence (227 residues)
MGASARLLRA VIMGAPGSGK GTVSSRITTH FELKHLSSGD LLRDNMLRGT EIGVLAKAFI DQGKLIPDDV MTRLALHELK NLTQYSWLLD GFPRTLPQAE ALDRAYQIDT VINLNVPFEV IKQRLTARWI HPASGRVYNI EFNPPKTVGI DDLTGEPLIQ REDDKPETVI KRLKAYEDQT KPVLEYYQKK GVLETFSGTE TNKIWPYVYA FLQTKVPQRS QKASVTP
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