Death-associated protein kinase 2 (DAPK2)

About Death-associated protein kinase 2

Death-associated protein kinase 2 (DAPK2) is a protein from Homo sapiens identified by UniProt accession Q9UIK4, 370 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	Death-associated protein kinase 2
UniProt accession	Q9UIK4
Gene	DAPK2
Organism	Homo sapiens
Length	370 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (7)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (70)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.49
death-associated protein kinase 2 measurement · score 0.31
t-tau:beta-amyloid 1-42 ratio measurement · score 0.29
breast adenocarcinoma · score 0.24
cutaneous melanoma · score 0.15
hemoglobin measurement · score 0.10
erythrocyte count · score 0.10
hematocrit · score 0.09
cystitis · score 0.07
mean corpuscular volume · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9UIK4-F1	alphafold	PREDICTED	86.44	—

Amino-acid sequence (370 residues)

MFQASMRSPN MEPFKQQKVE DFYDIGEELG SGQFAIVKKC REKSTGLEYA AKFIKKRQSR ASRRGVSREE IEREVSILRQ VLHHNVITLH DVYENRTDVV LILELVSGGE LFDFLAQKES LSEEEATSFI KQILDGVNYL HTKKIAHFDL KPENIMLLDK NIPIPHIKLI DFGLAHEIED GVEFKNIFGT PEFVAPEIVN YEPLGLEADM WSIGVITYIL LSGASPFLGD TKQETLANIT AVSYDFDEEF FSQTSELAKD FIRKLLVKET RKRLTIQEAL RHPWITPVDN QQAMVRRESV VNLENFRKQY VRRRWKLSFS IVSLCNHLTR SLMKKVHLRP DEDLRNCESD TEEDIARRKA LHPRRRSSTS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards