About Tomoregulin-2
Tomoregulin-2 (TMEFF2) is a protein
from Homo sapiens identified by UniProt accession
Q9UIK5, 374 residues long.
MolForge cross-references it against 0 known binders and
150 disease associations.
Target properties
| Protein name | Tomoregulin-2 |
|---|
| UniProt accession | Q9UIK5 |
|---|
| Gene | TMEFF2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 374 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (150)
Diseases linked to this target (Open Targets).
- body mass index · score 0.39
- visual perception measurement · score 0.32
- platelet count · score 0.30
- essential hypertension · score 0.23
- risk-taking behaviour · score 0.16
- Helicobacter pylori infectious disease · score 0.11
- neoplasm · score 0.08
- retinitis pigmentosa · score 0.08
- age-related macular degeneration · score 0.07
- Familial exudative vitreoretinopathy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9UIK5-F1 | alphafold | PREDICTED | 68.97 | — |
Amino-acid sequence (374 residues)
MVLWESPRQC SSWTLCEGFC WLLLLPVMLL IVARPVKLAA FPTSLSDCQT PTGWNCSGYD DRENDLFLCD TNTCKFDGEC LRIGDTVTCV CQFKCNNDYV PVCGSNGESY QNECYLRQAA CKQQSEILVV SEGSCATDAG SGSGDGVHEG SGETSQKETS TCDICQFGAE CDEDAEDVWC VCNIDCSQTN FNPLCASDGK SYDNACQIKE ASCQKQEKIE VMSLGRCQDN TTTTTKSEDG HYARTDYAEN ANKLEESARE HHIPCPEHYN GFCMHGKCEH SINMQEPSCR CDAGYTGQHC EKKDYSVLYV VPGPVRFQYV LIAAVIGTIQ IAVICVVVLC ITRKCPRSNR IHRQKQNTGH YSSDNTTRAS TRLI
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